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    PPA1 inorganic pyrophosphatase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 280701, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PPA1provided by VGNC
    Official Full Name
    inorganic pyrophosphatase 1provided by VGNC
    Primary source
    VGNC:VGNC:55992
    See related
    BGD:BT17549; Ensembl:ENSBTAG00000007836
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PP
    Orthologs
    human mouse all
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    Genomic context

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    See PPA1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (26418192..26456501, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101903896 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene neuropeptide FF receptor 1 Neighboring gene leucine rich repeat containing 20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and functional expression of cDNA encoding a mammalian inorganic pyrophosphatase. Yang Z, et al. J Biol Chem, 1992 Dec 5. PMID 1339444
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC139082

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inorganic pyrophosphatase
    Names
    PPase
    pyrophosphatase (inorganic) 1
    pyrophosphatase 1
    pyrophosphate phospho-hydrolase
    NP_001068586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075118.1 → NP_001068586.1  inorganic pyrophosphatase

      See identical proteins and their annotated locations for NP_001068586.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114891
      UniProtKB/Swiss-Prot
      P37980, Q1RMH6
      UniProtKB/TrEMBL
      A0AAA9TZD7
      Related
      ENSBTAP00000010311.2, ENSBTAT00000010311.3
      Conserved Domains (1) summary
      cl00217
      Location:4 → 241
      pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26418192..26456501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37980.2 GenPept UniProtKB/Swiss-Prot:P37980

    Gene LinkOut

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