CHGB chromogranin B [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CHGBprovided by VGNC
Official Full Name: chromogranin Bprovided by VGNC
Primary source: VGNC:VGNC:27290
See related: Ensembl:ENSBTAG00000011782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (48069202..48084157)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromogranin B was found to co-localize with secretogranin II and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2+ store vesicles.
Title: Presence of secretogranin II and high-capacity, low-affinity Ca2+ storage role in nucleoplasmic Ca2+ store vesicles.
CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum
Title: A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel.
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells
Title: Subcellular distribution of chromogranins A and B in bovine adrenal chromaffin cells.
chromogranin B has a role in the IP(3)-mediated Ca(2+) release mechanism of secretory granules
Title: Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B.
colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R)isoforms with chromogranin B to the extent that the majority of each IP(3)R isoform-labeling gold particles found in the nucleoplasm
Title: Presence of a nucleoplasmic complex composed of the inositol 1,4,5-trisphosphate receptor/Ca2+ channel, chromogranin B, and phospholipids.

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General gene information

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Markers

D20S732 (e-PCR)
- UniSTS:12973

CHGB (e-PCR)
- UniSTS:278199

Gene Ontology Provided by RefSeq

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: secretogranin-1

Names: cgB; chromogranin B (secretogranin 1); secretogranin I; sgI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.