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    BOLA-DRB3 major histocompatibility complex, class II, DRB3 [ Bos taurus (domestic cattle) ]

    Gene ID: 282530, updated on 1-Jan-2025

    Summary

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    Gene symbol
    BOLA-DRB3
    Gene description
    major histocompatibility complex, class II, DRB3
    See related
    Ensembl:ENSBTAG00000013919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DRB3; LA-DRB; BLA-DRB3; BoLA-DRB; Bota-DRB01; Bota-DRB02; Bota-DRB04; Bota-DRB07; Bota-DRB21; Bota-DRB22
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    Genomic context

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    See BOLA-DRB3 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (25723717..25734819)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene MHC class II antigen Neighboring gene SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like Neighboring gene DLA class II histocompatibility antigen, DR-1 beta chain-like Neighboring gene DR-beta chain pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. [Genetic mechanisms of resistance and susceptibility to leukemia in Ayrshire and black pied cattle breeds determined by allelic distribution of gene Bola-DRB3]. Udina IG, et al. Genetika, 2003 Mar. PMID 12722639
    2. Antibody response against three widespread bovine viruses is not impaired in Holstein cattle carrying bovine leukocyte antigen DRB3.2 alleles associated with bovine leukemia virus resistance. Juliarena MA, et al. J Dairy Sci, 2009 Jan. PMID 19109295
    3. PCR based RFLP genotyping of bovine lymphocyte antigen DRB3.2 in Iranian Holstein population. Pashmi M, et al. Pak J Biol Sci, 2007 Feb 1. PMID 19069505
    4. Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina. Valenzano MN, et al. Trop Anim Health Prod, 2021 Dec 24. PMID 34950978
    5. Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene. Juliarena MA, et al. Anim Genet, 2008 Aug. PMID 18573126

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina.
      Title: Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina.
    2. Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar.
      Title: Characterization of bovine MHC DRB3 diversity in global cattle breeds, with a focus on cattle in Myanmar.
    3. In this study, we showed that BoLA-DRB3 was a good marker for determining which cow spread Bovine leukemia virus, and we found not only one resistant allele (BoLA-DRB3*009:02), but also two other disease-resistant alleles and two disease-susceptible alleles.
      Title: Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan.
    4. It was concluded that the ability of cattle carrying resistance-associated marker BoLA DRB3*0902 to control bovine leukemia virus and to progress towards a low proviral load phenotype was not altered by M. bovis co-infection.
      Title: Co-infection with Mycobacterium bovis does not alter the response to bovine leukemia virus in BoLA DRB3*0902, genetically resistant cattle.
    5. The association of the bovine MHC class II BoLA-DRB3.2 alleles with Bovine leukemia virus infection profiles was examined.
      Title: Association of BoLA-DRB3.2 Alleles with BLV Infection Profiles (Persistent Lymphocytosis/Lymphosarcoma) and Lymphocyte Subsets in Iranian Holstein Cattle.
    6. This study showed that the effect of the genotype at the BoLA-DRB3 locus does not explain variation in somatic cell count and milk yield at a degree expected of a genetic marker.
      Title: Locus BoLA-DRB3 is just an ordinary site of the polygene when explaining genetic variance of somatic cell count and milk yield.
    7. Forty-six BoLA-DRB3 alleles have been identified in Chilean cattle.
      Title: Assessment of biodiversity in Chilean cattle using the distribution of major histocompatibility complex class II BoLA-DRB3 allele.
    8. polymorphisms associated with resistance and susceptibility to the bovine leukemia Virus progression
      Title: Identification of cattle carrying alleles associated with resistance and susceptibility to the Bovine Leukemia Virus progression by real-time PCR.
    9. The relationship between BoLA-DRB3 alleles and tick-borne disease resistance in Zebu and Holstein cross dairy cattle is reported.
      Title: Association of BoLA-DRB3 alleles with tick-borne disease tolerance in dairy cattle in a tropical environment.
    10. The results of this study demonstrated that the BoLA-DRB3.2 is a highly polymorphic locus, with significant breed-specific genetic diversities being present amongst the three studied cattle breeds.
      Title: Genetic diversity and population genetic analysis of bovine MHC class II DRB3.2 locus in three Bos indicus cattle breeds of Southern India.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128256

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antigen processing and presentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DRB3
    Names
    BoLA-DRB3.2
    DR beta-chain antigen binding domain
    DR-beta chain MHC class II
    MHC class II DR beta chain
    MHC class II DR beta chain beta domain
    MHC class II DRB3
    MHC class II antigen BoLA-DRB3
    MHC class II antigen beta chain
    MHC class II leukocyte antigen BoLA-DRB3
    MHC(BoLA) class II DR-beta chain
    histocompatibility complex, class II, DR beta 3
    leukocyte antigen DRB3
    major histocompatibility complex class II DR-beta chain
    major histocompatibility complex, class II, DR beta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012680.2 → NP_001012698.2  major histocompatibility complex, class II, DRB3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      U77067
      UniProtKB/TrEMBL
      P79465, Q1JP81
      Conserved Domains (2) summary
      pfam00969
      Location:42 → 116
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cl11960
      Location:126 → 219
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25723717..25734819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984096.2 → XP_024839864.1  major histocompatibility complex, class II, DRB3

      UniProtKB/TrEMBL
      A1L5C7
      Related
      ENSBTAP00000018484.5, ENSBTAT00000018484.6
      Conserved Domains (2) summary
      pfam00969
      Location:43 → 116
      MHC_II_beta; Class II histocompatibility antigen, beta domain
      cl11960
      Location:126 → 219
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials