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    EXT2 exostosin glycosyltransferase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281151, updated on 30-Jan-2025

    Summary

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    Official Symbol
    EXT2provided by VGNC
    Official Full Name
    exostosin glycosyltransferase 2provided by VGNC
    Primary source
    VGNC:VGNC:28666
    See related
    BGD:BT29415; EnsemblRapid:ENSBTAG00070029529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See EXT2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (74203811..74352953)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Neighboring gene ALX homeobox 4 Neighboring gene small nucleolar RNA SNORA61 Neighboring gene CD82 molecule

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis. Senay C, et al. EMBO Rep, 2000 Sep. PMID 11256613, Free PMC Article
    2. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. Lind T, et al. J Biol Chem, 1998 Oct 9. PMID 9756849
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exostosin-2
    Names
    HS-POL
    HS-polymerase
    exostoses (multiple) 2
    glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
    glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
    glucuronyl/N-acetylglucosaminyl transferase
    multiple exostoses protein 2 homolog
    NP_803462.2
    XP_005216463.2
    XP_005216464.1
    XP_010811099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177496.4 → NP_803462.2  exostosin-2

      Status: PROVISIONAL

      Source sequence(s)
      BC126570
      UniProtKB/Swiss-Prot
      O77783
      UniProtKB/TrEMBL
      A0JN91, F1N5Y6
      Related
      ENSBTAP00070041021.1, ENSBTAT00070067181.1
      Conserved Domains (2) summary
      pfam03016
      Location:100 → 380
      Exostosin; Exostosin family
      pfam09258
      Location:456 → 697
      Glyco_transf_64; Glycosyl transferase family 64 domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      74203811..74352953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216407.5 → XP_005216464.1  exostosin-2 isoform X3

      UniProtKB/Swiss-Prot
      O77783
      UniProtKB/TrEMBL
      A0JN91, F1N5Y6
      Conserved Domains (2) summary
      pfam03016
      Location:100 → 380
      Exostosin; Exostosin family
      pfam09258
      Location:456 → 697
      Glyco_transf_64; Glycosyl transferase family 64 domain

    2. XM_010812797.4 → XP_010811099.1  exostosin-2 isoform X2

      UniProtKB/Swiss-Prot
      O77783
      Related
      ENSBTAP00070041009.1, ENSBTAT00070067164.1
      Conserved Domains (2) summary
      pfam03016
      Location:100 → 380
      Exostosin; Exostosin family
      pfam09258
      Location:412 → 646
      Glyco_transf_64; Glycosyl transferase family 64 domain

    3. XM_005216406.5 → XP_005216463.2  exostosin-2 isoform X1

      UniProtKB/Swiss-Prot
      O77783
      Related
      ENSBTAP00070040881.1, ENSBTAT00070066967.1
      Conserved Domains (2) summary
      pfam03016
      Location:100 → 380
      Exostosin; Exostosin family
      pfam09258
      Location:456 → 674
      Glyco_transf_64; Glycosyl transferase family 64 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77783.1 GenPept UniProtKB/Swiss-Prot:O77783

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials