U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ABCA4 ATP binding cassette subfamily A member 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 281584, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    ABCA4provided by VGNC
    Official Full Name
    ATP binding cassette subfamily A member 4provided by VGNC
    Primary source
    VGNC:VGNC:25458
    See related
    Ensembl:ENSBTAG00000018010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    RmP
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ABCA4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (49386861..49530772)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344875 Neighboring gene uncharacterized LOC132344874 Neighboring gene Rho GTPase activating protein 29 Neighboring gene poly(rC)-binding protein 1-like Neighboring gene glutamate-cysteine ligase modifier subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Tsybovsky Y, et al. Structure, 2013 May 7. PMID 23562398, Free PMC Article
    2. N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR). Beharry S, et al. J Biol Chem, 2004 Dec 24. PMID 15471866
    3. Photoreceptor rim protein: partial sequences of cDNA show a high degree of similarity to ABC transporters. Thomson JL, et al. Curr Eye Res, 1997 Jul. PMID 9222095
    4. The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. Illing M, et al. J Biol Chem, 1997 Apr 11. PMID 9092582
    5. ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal. Quazi F, et al. Proc Natl Acad Sci U S A, 2014 Apr 1. PMID 24707049, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABCA4 can transport N-11-cis-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.
      Title: ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.
    2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction
      Title: Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.
    3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function
      Title: Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.
    4. results indicate that ATP binding cassette protein ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity
      Title: N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR).
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    retinal-specific phospholipid-transporting ATPase ABCA4
    Names
    ATP-binding cassette sub-family A member 4
    ATP-binding cassette, sub-family A (ABC1), member 4
    RIM ABC transporter
    RIM protein
    retinal-specific ATP-binding cassette transporter
    NP_776646.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174221.2 → NP_776646.1  retinal-specific phospholipid-transporting ATPase ABCA4

      See identical proteins and their annotated locations for NP_776646.1

      Status: PROVISIONAL

      Source sequence(s)
      U90126
      UniProtKB/Swiss-Prot
      F1MWM0, O02698
      Related
      ENSBTAP00000023982.5, ENSBTAT00000023982.6
      Conserved Domains (2) summary
      TIGR01257
      Location:1 → 2270
      rim_protein; retinal-specific rim ABC transporter
      cd03263
      Location:1936 → 2156
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49386861..49530772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1MWM0.2 GenPept UniProtKB/Swiss-Prot:F1MWM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.