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    SLC18A2 solute carrier family 18 member A2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282471, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SLC18A2provided by VGNC
    Official Full Name
    solute carrier family 18 member A2provided by VGNC
    Primary source
    VGNC:VGNC:34706
    See related
    BGD:BT11375; Ensembl:ENSBTAG00000004739
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See SLC18A2 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (37562825..37602785)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene ventral anterior homeobox 1 Neighboring gene potassium two pore domain channel subfamily K member 18 Neighboring gene PDZ domain containing 8 Neighboring gene uncharacterized LOC101908195

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules. Howell M, et al. FEBS Lett, 1994 Jan 24. PMID 8307150
    2. Expression and regulation of the bovine vesicular monoamine transporter gene. Krejci E, et al. FEBS Lett, 1993 Nov 29. PMID 7902299
    3. Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium. Stern-Bach Y, et al. Proc Natl Acad Sci U S A, 1992 Oct 15. PMID 1357668, Free PMC Article
    4. Regulation of the chromaffin granule catecholamine transporter in cultured bovine adrenal medullary cells: stimulus-biosynthesis coupling. Desnos C, et al. J Neurochem, 1992 Dec. PMID 1279122
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serotonin:sodium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptic vesicular amine transporter
    Names
    VAT2
    monoamine transporter
    solute carrier family 18 (vesicular monoamine), member 2
    solute carrier family 18 member 2
    vesicular amine transporter 2
    vesicular monoamine transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174653.2 → NP_777078.1  synaptic vesicular amine transporter

      See identical proteins and their annotated locations for NP_777078.1

      Status: PROVISIONAL

      Source sequence(s)
      U02876
      UniProtKB/Swiss-Prot
      Q27963, Q28211
      UniProtKB/TrEMBL
      A0AAA9SH93
      Related
      ENSBTAP00000006221.3, ENSBTAT00000006221.4
      Conserved Domains (3) summary
      cd06174
      Location:297 → 474
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00880
      Location:135 → 276
      2_A_01_02; Multidrug resistance protein
      pfam07690
      Location:133 → 440
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37562825..37602785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27963.1 GenPept UniProtKB/Swiss-Prot:Q27963

    Gene LinkOut

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    Research Materials