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    PRKCA protein kinase C alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 282001, updated on 1-Jan-2025

    Summary

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    Official Symbol
    PRKCAprovided by VGNC
    Official Full Name
    protein kinase C alphaprovided by VGNC
    Primary source
    VGNC:VGNC:33327
    See related
    BGD:BT10523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PKRCA
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCA in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (62664528..62975086)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC107131551 Neighboring gene microRNA mir-2284p Neighboring gene uncharacterized LOC132343139 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene uncharacterized LOC132343138

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Unloading of intercellular tension induces the directional translocation of PKCα. Sera T, et al. J Cell Physiol, 2019 Jun. PMID 30387146
    2. Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. Bornancin F, et al. J Biol Chem, 1997 Feb 7. PMID 9013603
    3. Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain. Aschrafi A, et al. Biochim Biophys Acta, 2003 Oct 20. PMID 14563411
    4. The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha. Yeong SS, et al. J Biol Chem, 2006 Oct 13. PMID 16895917
    5. Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments. Feitosa WB, et al. J Cell Physiol, 2020 Jul. PMID 31960444

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments.
      Title: Endoplasmic reticulum distribution during bovine oocyte activation is regulated by protein kinase C via actin filaments.
    2. The results of this study indicate the involvement of PKCalpha in the Ca (2+) signaling pathway in response to mechanical stress in endothelial cells.
      Title: Unloading of intercellular tension induces the directional translocation of PKCα.
    3. Mechanical stress induced biphasic and directional PKCalpha translocation
      Title: Spatial and temporal translocation of PKCα in single endothelial cell in response to mechanical stimulus.
    4. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
      Title: Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production.
    5. Significant changes in thin filament Ca2+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.
      Title: FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.
    6. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
      Title: Role of PKC-α in NF-κB-MT1-MMP-mediated activation of proMMP-2 by TNF-α in pulmonary artery smooth muscle cells.
    7. calcium-dependent phosphorylation of argininosuccinate synthase Ser-328 is mediated by PKCalpha
      Title: Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
    8. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin.
      Title: Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.
    9. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
      Title: Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.
    10. degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA
      Title: Protein kinase A and protein kinase C(alpha)/PPP1CC2 play opposing roles in the regulation of phosphatidylinositol 3-kinase activation in bovine sperm.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C alpha type
    Names
    PKC-A
    PKC-alpha
    NP_776860.1
    XP_024835381.1
    XP_024835382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174435.1 → NP_776860.1  protein kinase C alpha type

      See identical proteins and their annotated locations for NP_776860.1

      Status: PROVISIONAL

      Source sequence(s)
      M13973
      UniProtKB/Swiss-Prot
      P04409
      UniProtKB/TrEMBL
      B0JYP1
      Conserved Domains (4) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      smart00220
      Location:339 → 597
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05615
      Location:328 → 668
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      pfam00130
      Location:37 → 89
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      62664528..62975086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979613.2 → XP_024835381.1  protein kinase C alpha type isoform X1

      UniProtKB/TrEMBL
      B0JYP1
      Conserved Domains (3) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05615
      Location:328 → 684
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      pfam00130
      Location:37 → 89
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_024979614.2 → XP_024835382.1  protein kinase C alpha type isoform X2

      UniProtKB/TrEMBL
      B0JYP1
      Conserved Domains (3) summary
      cd04026
      Location:159 → 289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05587
      Location:342 → 620
      STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
      pfam00130
      Location:37 → 89
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04409.3 GenPept UniProtKB/Swiss-Prot:P04409

    Gene LinkOut

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