U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MSR1 macrophage scavenger receptor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281311, updated on 1-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    MSR1provided by VGNC
    Official Full Name
    macrophage scavenger receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:31704
    See related
    BGD:BT16011; Ensembl:ENSBTAG00000002885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MSR1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (20909945..20990322)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tumor suppressor candidate 3 Neighboring gene putative methyltransferase NSUN5C

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Rohrer L, et al. Nature, 1990 Feb 8. PMID 2300208
    2. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Kodama T, et al. Nature, 1990 Feb 8. PMID 2300204
    3. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Nakamura T, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785981
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synaptic cleft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    macrophage acetylated LDL receptor I and II

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113240.1 → NP_001106711.1  macrophage scavenger receptor types I and II isoform 1

      See identical proteins and their annotated locations for NP_001106711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and protein isoform (1).
      Source sequence(s)
      AJ677598, AM037916, DY085614, X51689
      UniProtKB/Swiss-Prot
      A5PJV2, P21758
      UniProtKB/TrEMBL
      A0AAF6YK38
      Related
      ENSBTAP00000003751.4, ENSBTAT00000003751.5
      Conserved Domains (4) summary
      pfam01391
      Location:279 → 333
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:352 → 452
      SR; Scavenger receptor Cys-rich
      pfam03523
      Location:120 → 168
      Macscav_rec; Macrophage scavenger receptor
      cl25732
      Location:111 → 253
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_174113.2 → NP_776538.1  macrophage scavenger receptor types I and II isoform 2

      See identical proteins and their annotated locations for NP_776538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a distinct terminal exon resulting in a shorter protein isoform (2).
      Source sequence(s)
      AM018111, DY085614, X51689, X54183
      UniProtKB/Swiss-Prot
      P21758
      Related
      ENSBTAP00000003755.5, ENSBTAT00000003755.6
      Conserved Domains (3) summary
      pfam01391
      Location:279 → 333
      Collagen; Collagen triple helix repeat (20 copies)
      pfam03523
      Location:120 → 168
      Macscav_rec; Macrophage scavenger receptor
      cl25732
      Location:111 → 253
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      20909945..20990322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21758.1 GenPept UniProtKB/Swiss-Prot:P21758

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials