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    DSC2 desmocollin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281128, updated on 1-Jan-2025

    Summary

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    Official Symbol
    DSC2provided by VGNC
    Official Full Name
    desmocollin 2provided by VGNC
    Primary source
    VGNC:VGNC:28213
    See related
    BGD:BT10086; Ensembl:ENSBTAG00000040584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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    Genomic context

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    See DSC2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (26027401..26065770)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904557 Neighboring gene desmocollin 1 Neighboring gene desmocollin 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Complexity and expression patterns of the desmosomal cadherins. Koch PJ, et al. Proc Natl Acad Sci U S A, 1992 Jan 1. PMID 1729705, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of catenin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    desmocollin-2
    Names
    epithelial type 2 desmocollin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166526.1 → NP_001159998.1  desmocollin-2 precursor

      See identical proteins and their annotated locations for NP_001159998.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000024
      UniProtKB/TrEMBL
      F1MZF2
      Related
      ENSBTAP00000011306.6, ENSBTAT00000011306.7
      Conserved Domains (4) summary
      cd11304
      Location:247 → 351
      Cadherin_repeat; Cadherin tandem repeat domain
      smart01055
      Location:31 → 111
      Cadherin_pro; Cadherin prodomain like
      pfam00028
      Location:360 → 461
      Cadherin; Cadherin domain
      pfam01049
      Location:842 → 904
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26027401..26065770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005223953.5 → XP_005224010.1  desmocollin-2 isoform X1

      UniProtKB/TrEMBL
      F1MZF2
      Conserved Domains (4) summary
      cd11304
      Location:244 → 348
      Cadherin_repeat; Cadherin tandem repeat domain
      smart01055
      Location:31 → 111
      Cadherin_pro; Cadherin prodomain like
      pfam00028
      Location:357 → 458
      Cadherin; Cadherin domain
      pfam01049
      Location:839 → 901
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_005223955.5 → XP_005224012.1  desmocollin-2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M6K2, F1MZF2
      Related
      ENSBTAP00000066007.1, ENSBTAT00000084805.2
      Conserved Domains (3) summary
      cd11304
      Location:247 → 351
      Cadherin_repeat; Cadherin tandem repeat domain
      smart01055
      Location:31 → 111
      Cadherin_pro; Cadherin prodomain like
      pfam00028
      Location:360 → 461
      Cadherin; Cadherin domain

    3. XM_059880750.1 → XP_059736733.1  desmocollin-2 isoform X3

      UniProtKB/TrEMBL
      F1MZF2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33545.1 GenPept UniProtKB/Swiss-Prot:P33545

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials