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    PTGFR prostaglandin F receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 282020, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PTGFRprovided by VGNC
    Official Full Name
    prostaglandin F receptorprovided by VGNC
    Primary source
    VGNC:VGNC:50251
    See related
    BGD:BT26886; Ensembl:ENSBTAG00000015902
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PTGFR in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (66127446..66193901, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-10184 Neighboring gene sentrin-specific protease 8-like Neighboring gene surfeit locus protein 6-like Neighboring gene uncharacterized LOC112445883

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. E-ring isoprostane augments cholinergic neurotransmission in bovine trachealis via FP prostanoid receptors. Paredes C, et al. Am J Respir Cell Mol Biol, 2007 Dec. PMID 17630320
    2. Genomic organization and characterization of the gene encoding bovine prostaglandin F2alpha receptor. Ezashi T, et al. Gene, 1997 May 6. PMID 9197544
    3. Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor. Sakamoto K, et al. J Biol Chem, 1994 Feb 4. PMID 7508922
    4. PKC epsilon and an increase in intracellular calcium concentration are necessary for PGF2 alpha to inhibit LH-stimulated progesterone secretion in cultured bovine steroidogenic luteal cells. Goravanahally MP, et al. Reprod Biol Endocrinol, 2007 Aug 30. PMID 17760987, Free PMC Article
    5. Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping. Nakata LC, et al. Cytogenet Genome Res, 2006. PMID 16717461

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that OVGP1 expression in oviductal epithelial cells is enhanced by PGE2 via PTGER2-cAMP-PKA signaling, and reduced by PGF2alpha through PTGFR-Ca2+-PKC pathway. (OVGP1 = oviductal glycoprotein 1; PTGER2 = prostaglandin E2 receptor; PTGFR = prostaglandin F2-alpha receptor; PKA = cyclic AMP-dependent protein kinase; PKC = protein kinase C)
      Title: The prostaglandin E(2) receptor PTGER2 and prostaglandin F(2α) receptor PTGFR mediate oviductal glycoprotein 1 expression in bovine oviductal epithelial cells.
    2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor).
      Title: Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle.
    3. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
      Title: Different expression of PGE synthase, PGF receptor, TNF, Fas and oxytocin in the bovine corpus luteum of the estrous cycle and pregnancy.
    4. 15-E2t-IsoP acts upon an FP receptor on the cholinergic nerve endings, leading to enhanced neurotransmission.
      Title: E-ring isoprostane augments cholinergic neurotransmission in bovine trachealis via FP prostanoid receptors.
    5. COX-2 and FP receptor contribute via changes in amount and distribution to mechanisms associated with parturition.
      Title: Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term.
    6. Mapped to bovine chromosome 3.
      Title: Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables prostaglandin F receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostaglandin F2-alpha receptor
    Names
    FP prostanoid receptor
    PGF receptor
    PGF2-alpha receptor
    prostaglandin F receptor (FP)
    prostanoid FP receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181025.3 → NP_851368.1  prostaglandin F2-alpha receptor

      See identical proteins and their annotated locations for NP_851368.1

      Status: PROVISIONAL

      Source sequence(s)
      D17395
      UniProtKB/Swiss-Prot
      P37289
      UniProtKB/TrEMBL
      A0A3Q1MIS6
      Related
      ENSBTAP00000041321.2, ENSBTAT00000043776.3
      Conserved Domains (1) summary
      pfam00001
      Location:44 → 304
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      66127446..66193901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984696.2 → XP_024840464.1  prostaglandin F2-alpha receptor isoform X1

      UniProtKB/TrEMBL
      A0A140T8B9, A0A3Q1MIS6
      Conserved Domains (1) summary
      cd15145
      Location:27 → 316
      7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_005204371.5 → XP_005204428.1  prostaglandin F2-alpha receptor isoform X1

      See identical proteins and their annotated locations for XP_005204428.1

      UniProtKB/TrEMBL
      A0A140T8B9, A0A3Q1MIS6
      Conserved Domains (1) summary
      cd15145
      Location:27 → 316
      7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37289.1 GenPept UniProtKB/Swiss-Prot:P37289

    Gene LinkOut

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