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    PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 407109, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PDHA1provided by VGNC
    Official Full Name
    pyruvate dehydrogenase E1 subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:56948
    See related
    BGD:BT28874; EnsemblRapid:ENSBTAG00070028555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PDHA
    Orthologs
    human mouse all
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    Genomic context

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    See PDHA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (123763235..123786122, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene SH3 domain containing kinase binding protein 1 Neighboring gene microRNA mir-10176 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene uncharacterized LOC112445136 Neighboring gene uncharacterized LOC784741 Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Names
    PDHE1-A type I
    pyruvate dehydrogenase (lipoamide) alpha 1
    pyruvate dehydrogenase E1 alpha 1 subunit
    pyruvate dehydrogenase E1 component alpha subunit
    pyruvate dehydrogenase alpha 1
    NP_001094516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101046.2 → NP_001094516.1  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001094516.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151313
      UniProtKB/Swiss-Prot
      A7MB35
      UniProtKB/TrEMBL
      A0A452DJH4
      Related
      ENSBTAP00070039245.1, ENSBTAT00070065109.1
      Conserved Domains (1) summary
      TIGR03182
      Location:58 → 369
      PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      123763235..123786122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7MB35.1 GenPept UniProtKB/Swiss-Prot:A7MB35

    Gene LinkOut

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    Research Materials