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    PLK4 polo like kinase 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 514405, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PLK4provided by VGNC
    Official Full Name
    polo like kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:33036
    See related
    BGD:BT23641; EnsemblRapid:ENSBTAG00070004212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PLK-4
    Orthologs
    human mouse all
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    Genomic context

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    See PLK4 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (29774982..29792009, complement)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene abhydrolase domain containing 18 Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene uncharacterized LOC112442024 Neighboring gene large ribosomal subunit protein uL15-like Neighboring gene heat shock protein family A (Hsp70) member 4 like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Polo-like kinase 4 regulates spindle and actin assembly in meiosis and influence of early embryonic development in bovine oocytes. Liang S, et al. Theriogenology, 2016 Mar 1. PMID 26549124
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicated that PLK4 plays crucial roles in bovine oocyte meiotic maturation and subsequent early embryo development.
      Title: Polo-like kinase 4 regulates spindle and actin assembly in meiosis and influence of early embryonic development in bovine oocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PLK4
    Names
    serine/threonine-protein kinase Sak
    NP_001076896.1
    XP_010812038.1
    XP_010812039.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083427.2 → NP_001076896.1  serine/threonine-protein kinase PLK4

      See identical proteins and their annotated locations for NP_001076896.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133488
      UniProtKB/Swiss-Prot
      A2VDZ4
      UniProtKB/TrEMBL
      A0AAA9TN56
      Related
      ENSBTAP00070005425.1, ENSBTAT00070009564.1
      Conserved Domains (5) summary
      smart00220
      Location:12 → 265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:510 → 621
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:622 → 730
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:807 → 886
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10 → 265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29774982..29792009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010813736.3 → XP_010812038.1  serine/threonine-protein kinase PLK4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TN56
      Conserved Domains (5) summary
      smart00220
      Location:12 → 265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:510 → 621
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:622 → 728
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:806 → 885
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10 → 265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

    2. XM_010813737.4 → XP_010812039.1  serine/threonine-protein kinase PLK4 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TCT4
      Conserved Domains (5) summary
      smart00220
      Location:5 → 218
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:463 → 574
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:575 → 683
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:760 → 839
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cl21453
      Location:1 → 218
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VDZ4.1 GenPept UniProtKB/Swiss-Prot:A2VDZ4

    Gene LinkOut

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