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    CNKSR2 connector enhancer of kinase suppressor of Ras 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 534112, updated on 30-Jan-2025

    Summary

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    Official Symbol
    CNKSR2provided by VGNC
    Official Full Name
    connector enhancer of kinase suppressor of Ras 2provided by VGNC
    Primary source
    VGNC:VGNC:27505
    See related
    EnsemblRapid:ENSBTAG00070032491
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CNKSR2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (121644936..121954170, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene membrane bound transcription factor peptidase, site 2 Neighboring gene small muscle protein X-linked Neighboring gene kelch like family member 34 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene U6 spliceosomal RNA Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene large ribosomal subunit protein P2-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    connector enhancer of kinase suppressor of ras 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206513.2 → NP_001193442.1  connector enhancer of kinase suppressor of ras 2

      See identical proteins and their annotated locations for NP_001193442.1

      Status: INFERRED

      Source sequence(s)
      NKLS02000030
      UniProtKB/TrEMBL
      A0AAA9T9U9, F1N773
      Related
      ENSBTAP00070044984.1, ENSBTAT00070073846.1
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559 → 672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573 → 669
      PH; PH domain
      pfam06663
      Location:341 → 561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      121644936..121954170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005228380.5 → XP_005228437.1  connector enhancer of kinase suppressor of ras 2 isoform X1

      See identical proteins and their annotated locations for XP_005228437.1

      UniProtKB/TrEMBL
      A0AAA9SLM7, A0AAA9T9U9
      Related
      ENSBTAP00070045020.1, ENSBTAT00070073903.1
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:529 → 642
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:543 → 639
      PH; PH domain
      pfam06663
      Location:341 → 531
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    2. XM_024988116.2 → XP_024843884.1  connector enhancer of kinase suppressor of ras 2 isoform X3

      UniProtKB/TrEMBL
      A0AAA9T9U9
      Conserved Domains (5) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      cd00992
      Location:222 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:480 → 593
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam06663
      Location:292 → 408
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

    3. XM_005228381.5 → XP_005228438.1  connector enhancer of kinase suppressor of ras 2 isoform X2

      See identical proteins and their annotated locations for XP_005228438.1

      UniProtKB/TrEMBL
      A0AAA9T9U9
      Related
      ENSBTAP00070045005.1, ENSBTAT00070073878.1
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:510 → 623
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:524 → 620
      PH; PH domain
      pfam06663
      Location:292 → 512
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    4. XM_005228382.5 → XP_005228439.1  connector enhancer of kinase suppressor of ras 2 isoform X4

      See identical proteins and their annotated locations for XP_005228439.1

      UniProtKB/TrEMBL
      A0AAA9SUC2, A0AAA9T9U9
      Related
      ENSBTAP00070044921.1, ENSBTAT00070073728.1
      Conserved Domains (8) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:8 → 73
      SAM; Sterile alpha motif
      cd00992
      Location:222 → 294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559 → 672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573 → 669
      PH; PH domain
      pfam06663
      Location:341 → 561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139 → 218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    5. XM_024988118.2 → XP_024843886.1  connector enhancer of kinase suppressor of ras 2 isoform X5

      UniProtKB/TrEMBL
      A0AAA9TUQ2
      Conserved Domains (5) summary
      cd09511
      Location:8 → 76
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      cd00992
      Location:222 → 270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:480 → 593
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam06663
      Location:292 → 408
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84 → 176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    Nucleotide Protein Strain
    Heading Accession and Version

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