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    PARG poly(ADP-ribose) glycohydrolase [ Bos taurus (domestic cattle) ]

    Gene ID: 281377, updated on 30-Jan-2025

    Summary

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    Gene symbol
    PARG
    Gene description
    poly(ADP-ribose) glycohydrolase
    See related
    BGD:BT26615; EnsemblRapid:ENSBTAG00070017767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PARG in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (43900411..44015134, complement)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344154 Neighboring gene chromosome 28 C10orf53 homolog Neighboring gene oxoglutarate dehydrogenase L Neighboring gene small nucleolar RNA SNORA74 Neighboring gene translocase of inner mitochondrial membrane 23 homolog (yeast) Neighboring gene uncharacterized LOC132344155 Neighboring gene nuclear receptor coactivator 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. Lin W, et al. J Biol Chem, 1997 May 2. PMID 9115250
    2. Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells. Bernardi R, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074616
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables poly(ADP-ribose) glycohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poly(ADP-ribose) glycohydrolase
    NP_776563.1
    XP_010819000.2
    XP_010819001.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174138.3 → NP_776563.1  poly(ADP-ribose) glycohydrolase

      See identical proteins and their annotated locations for NP_776563.1

      Status: PROVISIONAL

      Source sequence(s)
      U78975
      UniProtKB/Swiss-Prot
      O02776
      UniProtKB/TrEMBL
      F1MG95
      Related
      ENSBTAP00070023591.1, ENSBTAT00070040033.1
      Conserved Domains (2) summary
      PHA03169
      Location:161 → 482
      PHA03169; hypothetical protein; Provisional
      pfam05028
      Location:582 → 910
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      43900411..44015134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010820699.4 → XP_010819001.2  poly(ADP-ribose) glycohydrolase isoform X1

      UniProtKB/TrEMBL
      F1MG95
      Conserved Domains (1) summary
      pfam05028
      Location:499 → 827
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

    2. XM_010820698.4 → XP_010819000.2  poly(ADP-ribose) glycohydrolase isoform X1

      UniProtKB/TrEMBL
      F1MG95
      Conserved Domains (1) summary
      pfam05028
      Location:499 → 827
      PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02776.1 GenPept UniProtKB/Swiss-Prot:O02776

    Gene LinkOut

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    Research Materials