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    FANCM FA complementation group M [ Bos taurus (domestic cattle) ]

    Gene ID: 513626, updated on 1-Jan-2025

    Summary

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    Official Symbol
    FANCMprovided by VGNC
    Official Full Name
    FA complementation group Mprovided by VGNC
    Primary source
    VGNC:VGNC:106735
    See related
    BGD:BT22243; Ensembl:ENSBTAG00000002612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FANCM in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (54856776..54915450)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA SNORD127 Neighboring gene FKBP prolyl isomerase 3 Neighboring gene MIS18 binding protein 1 Neighboring gene PRELI domain-containing protein 1, mitochondrial-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC148519

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables four-way junction DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via synthesis-dependent strand annealing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fanconi anemia group M protein
    Names
    Fanconi anemia complementation group M
    NP_001098446.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104976.2 → NP_001098446.2  Fanconi anemia group M protein

      Status: VALIDATED

      Source sequence(s)
      BC149286, DAAA02052960
      UniProtKB/TrEMBL
      A0A3Q1MT39
      Related
      ENSBTAP00000003379.7, ENSBTAT00000003379.7
      Conserved Domains (6) summary
      COG1111
      Location:89 → 623
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:112 → 254
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd12091
      Location:304 → 419
      FANCM_ID; Insert domain of FANCM and related proteins
      pfam00271
      Location:478 → 585
      Helicase_C; Helicase conserved C-terminal domain
      pfam02732
      Location:1811 → 1937
      ERCC4; ERCC4 domain
      pfam16783
      Location:681 → 795
      FANCM-MHF_bd; FANCM to MHF binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54856776..54915450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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