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    XRN2 5'-3' exoribonuclease 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 517417, updated on 1-Jan-2025

    Summary

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    Official Symbol
    XRN2provided by VGNC
    Official Full Name
    5'-3' exoribonuclease 2provided by VGNC
    Primary source
    VGNC:VGNC:37009
    See related
    BGD:BT17340; Ensembl:ENSBTAG00000011304
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See XRN2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (40615497..40678291)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene kizuna centrosomal protein Neighboring gene S-phase kinase-associated protein 2-like Neighboring gene uncharacterized LOC112449289 Neighboring gene NK2 homeobox 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5'-3' exoribonuclease 2
    NP_001179401.1
    XP_010809536.1
    XP_010809537.1
    XP_024856352.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192472.1 → NP_001179401.1  5'-3' exoribonuclease 2

      See identical proteins and their annotated locations for NP_001179401.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000013
      UniProtKB/TrEMBL
      A0A3Q1N603, F1MKX7
      Related
      ENSBTAP00000015019.4, ENSBTAT00000015019.5
      Conserved Domains (2) summary
      COG5049
      Location:1 → 787
      XRN1; 5'-3' exonuclease [Replication, recombination and repair]
      pfam03159
      Location:1 → 253
      XRN_N; XRN 5'-3' exonuclease N-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40615497..40678291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010811235.4 → XP_010809537.1  5'-3' exoribonuclease 2 isoform X2

      See identical proteins and their annotated locations for XP_010809537.1

      UniProtKB/TrEMBL
      A0A3Q1N603
      Conserved Domains (2) summary
      COG5049
      Location:1 → 733
      XRN1; 5'-3' exonuclease [Replication, recombination and repair]
      pfam03159
      Location:1 → 199
      XRN_N; XRN 5'-3' exonuclease N-terminus

    2. XM_010811234.4 → XP_010809536.1  5'-3' exoribonuclease 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LQQ3, A0A3Q1N603
      Related
      ENSBTAP00000057327.1, ENSBTAT00000071117.2
      Conserved Domains (2) summary
      COG5049
      Location:1 → 751
      XRN1; 5'-3' exonuclease [Replication, recombination and repair]
      pfam03159
      Location:1 → 253
      XRN_N; XRN 5'-3' exonuclease N-terminus

    3. XM_025000584.2 → XP_024856352.1  5'-3' exoribonuclease 2 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1N603
      Conserved Domains (2) summary
      pfam09606
      Location:694 → 871
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl27292
      Location:1 → 711
      XRN_N; XRN 5'-3' exonuclease N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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