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    CRHR2 corticotropin releasing hormone receptor 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 521831, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CRHR2provided by VGNC
    Official Full Name
    corticotropin releasing hormone receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:27709
    See related
    Ensembl:ENSBTAG00000014381
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CRHR2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (65647884..65692602)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene oxysterol-binding protein-related protein 9-like Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene indolethylamine N-methyltransferase Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC132345106

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland. Squillacioti C, et al. Gen Comp Endocrinol, 2011 Jul 1. PMID 21504748
    2. Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland. Squillacioti C, et al. Anat Histol Embryol, 2014 Dec. PMID 24219151
    3. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
      Title: Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.
    2. CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
      Title: Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotrophin-releasing factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corticotropin-releasing factor receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192545.1 → NP_001179474.1  corticotropin-releasing factor receptor 2

      See identical proteins and their annotated locations for NP_001179474.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      A0A3Q1N5S8
      Related
      ENSBTAP00000065623.2, ENSBTAT00000081022.2
      Conserved Domains (2) summary
      smart00008
      Location:36 → 107
      HormR; Domain present in hormone receptors
      pfam00002
      Location:113 → 355
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65647884..65692602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005205492.5 → XP_005205549.1  corticotropin-releasing factor receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M141
      Related
      ENSBTAP00000061738.1, ENSBTAT00000082923.2
      Conserved Domains (2) summary
      smart00008
      Location:61 → 132
      HormR; Domain present in hormone receptors
      pfam00002
      Location:138 → 380
      7tm_2; 7 transmembrane receptor (Secretin family)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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