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    ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase [ Bos taurus (domestic cattle) ]

    Gene ID: 540876, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ABL1provided by VGNC
    Official Full Name
    ABL proto-oncogene 1, non-receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:50224
    See related
    BGD:BT28137; Ensembl:ENSBTAG00000017976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ABL1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (100989350..101131026)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 12 Neighboring gene exosome component 2 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene fibrinogen C domain containing 1 Neighboring gene transfer RNA glycine (anticodon CCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    Abelson murine leukemia viral (v-abl) oncogene homolog 1
    c-abl oncogene 1, non-receptor tyrosine kinase
    c-abl oncogene 1, receptor tyrosine kinase
    v-abl Abelson murine leukemia viral oncogene homolog 1
    NP_001193789.1
    XP_024854844.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206860.1 → NP_001193789.1  tyrosine-protein kinase ABL1

      See identical proteins and their annotated locations for NP_001193789.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      A0A3Q1LI98
      Related
      ENSBTAP00000058693.1, ENSBTAT00000080797.2
      Conserved Domains (5) summary
      smart00808
      Location:1027 → 1151
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:142 → 235
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:84 → 137
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:254 → 516
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:261 → 512
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100989350..101131026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999076.2 → XP_024854844.1  tyrosine-protein kinase ABL1 isoform X1

      UniProtKB/TrEMBL
      F1MXG8
      Related
      ENSBTAP00000023920.6, ENSBTAT00000023920.7
      Conserved Domains (5) summary
      smart00808
      Location:1008 → 1132
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:123 → 216
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:65 → 118
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:235 → 497
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cl26464
      Location:622 → 1023
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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