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    DPYD dihydropyrimidine dehydrogenase [ Bos taurus (domestic cattle) ]

    Gene ID: 281124, updated on 1-Jan-2025

    Summary

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    Official Symbol
    DPYDprovided by VGNC
    Official Full Name
    dihydropyrimidine dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:28193
    See related
    BGD:BT14767; Ensembl:ENSBTAG00000031358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DPYD in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (45408337..46330781)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC domain-containing protein 17-like Neighboring gene microRNA mir-137 Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132344995 Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of bovine liver dihydropyrimidine dehydrogenase. Albin N, et al. DNA Seq, 1996. PMID 8912928
    2. Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil. Porter DJ, et al. J Biol Chem, 1991 Oct 25. PMID 1939061
    3. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Lu Z, et al. Cancer Res, 1993 Nov 15. PMID 8221682
    4. Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties. Lu ZH, et al. Biochem Pharmacol, 1993 Sep 1. PMID 8373446
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC179396

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables uracil binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thymine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in uracil catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydropyrimidine dehydrogenase [NADP(+)]
    Names
    DHPDHase
    DPD
    dihydrothymine dehydrogenase
    dihydrouracil dehydrogenase
    NP_776466.1
    XP_059737496.1
    XP_059737500.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174041.2 → NP_776466.1  dihydropyrimidine dehydrogenase [NADP(+)]

      See identical proteins and their annotated locations for NP_776466.1

      Status: PROVISIONAL

      Source sequence(s)
      U20981
      UniProtKB/Swiss-Prot
      Q28007, Q9TRV4
      UniProtKB/TrEMBL
      F1N549
      Related
      ENSBTAP00000007139.5, ENSBTAT00000007139.6
      Conserved Domains (6) summary
      PRK08318
      Location:532 → 1007
      PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
      PRK11749
      Location:53 → 513
      PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam13187
      Location:953 → 997
      Fer4_9; 4Fe-4S dicluster domain
      pfam13450
      Location:193 → 238
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam14691
      Location:56 → 168
      Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45408337..46330781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881513.1 → XP_059737496.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

    2. XM_059881517.1 → XP_059737500.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

      UniProtKB/TrEMBL
      A7YY69
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28007.1 GenPept UniProtKB/Swiss-Prot:Q28007

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials