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    A2M alpha-2-macroglobulin [ Bos taurus (domestic cattle) ]

    Gene ID: 513856, updated on 1-Jan-2025

    Summary

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    Official Symbol
    A2Mprovided by VGNC
    Official Full Name
    alpha-2-macroglobulinprovided by VGNC
    Primary source
    VGNC:VGNC:55837
    See related
    BGD:BT30437; Ensembl:ENSBTAG00000018137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See A2M in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (100819129..100891539)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene pregnancy zone protein Neighboring gene killer cell lectin like receptor G1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene mannose-6-phosphate receptor, cation dependent

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Regulatory mutations in the A2M gene are involved in the mastitis susceptibility in dairy cows. Wang XG, et al. Anim Genet, 2014 Feb. PMID 25237709
    2. The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle. Wang X, et al. Immunogenetics, 2012 Nov. PMID 22923050
    3. Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles. Ireland JL, et al. Endocrinology, 2004 Jun. PMID 15001551
    4. Crystal structure of the receptor-binding domain of alpha 2-macroglobulin. Jenner L, et al. Structure, 1998 May 15. PMID 9634697
    5. Secreted phosphoprotein-24 kDa (Spp24) attenuates BMP-2-stimulated Smad 1/5 phosphorylation and alkaline phosphatase induction and was purified in a protective complex with alpha2 -Macroglobulins From Serum. Zhao KW, et al. J Cell Biochem, 2013 Feb. PMID 22949401

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.
      Title: Regulatory mutations in the A2M gene are involved in the mastitis susceptibility in dairy cows.
    2. We report here for the first time the direct isolation of Spp24 covalently bound to alpha2-macroglobulins as a core complex (Spp24-alpha2M) from bovine calf serum.
      Title: Secreted phosphoprotein-24 kDa (Spp24) attenuates BMP-2-stimulated Smad 1/5 phosphorylation and alkaline phosphatase induction and was purified in a protective complex with alpha2 -Macroglobulins From Serum.
    3. Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.
      Title: The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle.
    4. Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.
      Title: Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles.
    5. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5
      Title: Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
    6. These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
      Title: Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-2-macroglobulin
    Names
    alpha-2-M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109795.2 → NP_001103265.1  alpha-2-macroglobulin precursor

      See identical proteins and their annotated locations for NP_001103265.1

      Status: PROVISIONAL

      Source sequence(s)
      BC153840
      UniProtKB/Swiss-Prot
      A8E647, Q7SIH1
      UniProtKB/TrEMBL
      A0AAA9SFM6
      Related
      ENSBTAP00000057998.2, ENSBTAT00000075123.2
      Conserved Domains (7) summary
      cd02897
      Location:995 → 1301
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam05326
      Location:792 → 884
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1413 → 1499
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1047 → 1303
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:461 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      100819129..100891539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207056.4 → XP_005207113.1  alpha-2-macroglobulin isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFM6, A0AAA9SKJ1
      Related
      ENSBTAP00000083137.1, ENSBTAT00000092217.1
      Conserved Domains (7) summary
      cd02897
      Location:995 → 1301
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:740 → 830
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam05326
      Location:792 → 884
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1413 → 1499
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1047 → 1303
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:461 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SIH1.2 GenPept UniProtKB/Swiss-Prot:Q7SIH1

    Gene LinkOut

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    Research Materials