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    SLC6A2 solute carrier family 6 member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282363, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SLC6A2provided by VGNC
    Official Full Name
    solute carrier family 6 member 2provided by VGNC
    Primary source
    VGNC:VGNC:34920
    See related
    EnsemblRapid:ENSBTAG00070018681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SLC6A2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (23885168..23927951)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene calpain small subunit 2 Neighboring gene transfer RNA phenylalanine (anticodon GAA) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene uncharacterized LOC132342811 Neighboring gene carboxylesterase 1 (monocyte/macrophage serine esterase 1)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter. Lingen B, et al. FEBS Lett, 1994 Apr 11. PMID 8150077
    2. Structure, function and brain localization of neurotransmitter transporters. Jursky F, et al. J Exp Biol, 1994 Nov. PMID 7823028
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables dopamine:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables norepinephrine:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine uptake involved in synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in norepinephrine transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium-dependent noradrenaline transporter
    Names
    NET
    norepinephrine transporter
    solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174608.2 → NP_777033.1  sodium-dependent noradrenaline transporter

      See identical proteins and their annotated locations for NP_777033.1

      Status: PROVISIONAL

      Source sequence(s)
      X79015
      UniProtKB/Swiss-Prot
      P51143
      UniProtKB/TrEMBL
      A0A3Q1N0K4
      Related
      ENSBTAP00070025202.1, ENSBTAT00070042238.1
      Conserved Domains (1) summary
      cl00456
      Location:54 → 613
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23885168..23927951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015475703.3 → XP_015331189.1  sodium-dependent noradrenaline transporter isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MQW2, A0A3Q1N0K4
      Related
      ENSBTAP00070025225.1, ENSBTAT00070042268.1
      Conserved Domains (1) summary
      cl00456
      Location:54 → 610
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_024977953.2 → XP_024833721.1  sodium-dependent noradrenaline transporter isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M4L9, A0A3Q1MWL4
      Related
      ENSBTAP00070025218.1, ENSBTAT00070042258.1
      Conserved Domains (1) summary
      cl00456
      Location:54 → 582
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51143.1 GenPept UniProtKB/Swiss-Prot:P51143

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials