BHLHE40 basic helix-loop-helix family member e40 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: BHLHE40provided by VGNC
Official Full Name: basic helix-loop-helix family member e40provided by VGNC
Primary source: VGNC:VGNC:26486
See related: Ensembl:ENSBTAG00000009863
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: DEC1; BHLHB2
Summary: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (21400624..21406265, complement)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

overexpression of DEC1 blocked myogenesis by inhibiting MyoG promoter activity in bovine.
Title: Over-expression of DEC1 inhibits myogenic differentiation by modulating MyoG activity in bovine satellite cell.
This study aimed to lay the groundwork to further study of Bhlhe40 function at myogenesis and adipogenesis in bovine and should significantly contribute to cattle breeding and genetics through MAS program
Title: [Developmental expression patterns and association study with growth traits of bovine].

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: class E basic helix-loop-helix protein 40

Names: basic helix-loop-helix domain containing, class B, 2; class B basic helix-loop-helix protein 2; differentiated embryo chondrocyte expressed gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024929.1 → NP_001020100.1 class E basic helix-loop-helix protein 40

See identical proteins and their annotated locations for NP_001020100.1

Status: PROVISIONAL

Source sequence(s)

BT020754

UniProtKB/Swiss-Prot

Q5EA15

Related

ENSBTAP00000013008.3, ENSBTAT00000013008.4

Conserved Domains (2) summary

smart00511
Location:140 → 184

ORANGE; Orange domain

cd00083
Location:50 → 111

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...