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    HACL1 2-hydroxyacyl-CoA lyase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 512676, updated on 1-Feb-2025

    Summary

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    Official Symbol
    HACL1provided by VGNC
    Official Full Name
    2-hydroxyacyl-CoA lyase 1provided by VGNC
    Primary source
    VGNC:VGNC:29740
    See related
    BGD:BT12424; EnsemblRapid:ENSBTAG00070025990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See HACL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (152599802..152638556, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 6, methylcytidine Neighboring gene ELL associated factor 1 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene biotinidase Neighboring gene ankyrin repeat domain 28 Neighboring gene forkhead box protein E3 Neighboring gene microRNA mir-2285ao-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC160090

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-hydroxyacyl-CoA lyase 1
    Names
    2-hydroxyphytanoyl-CoA lyase
    NP_001092419.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098949.1 → NP_001092419.1  2-hydroxyacyl-CoA lyase 1

      See identical proteins and their annotated locations for NP_001092419.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142160
      UniProtKB/TrEMBL
      A0AAA9T585, A5PJL6
      Related
      ENSBTAP00070035064.1, ENSBTAT00070059100.1
      Conserved Domains (4) summary
      cd07035
      Location:22 → 175
      TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
      PRK09259
      Location:19 → 564
      PRK09259; putative oxalyl-CoA decarboxylase; Validated
      cd02004
      Location:380 → 563
      TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
      pfam00205
      Location:209 → 335
      TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      152599802..152638556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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