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    CARS2 cysteinyl-tRNA synthetase 2, mitochondrial [ Bos taurus (domestic cattle) ]

    Gene ID: 506598, updated on 30-Jan-2025

    Summary

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    Official Symbol
    CARS2provided by VGNC
    Official Full Name
    cysteinyl-tRNA synthetase 2, mitochondrialprovided by VGNC
    Primary source
    VGNC:VGNC:49547
    See related
    BGD:BT29180; EnsemblRapid:ENSBTAG00070010567
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CARS2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (85239190..85268251, complement)

    Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene RAB20, member RAS oncogene family Neighboring gene uncharacterized LOC132346802 Neighboring gene NAD(P)HX dehydratase Neighboring gene inhibitor of growth family member 1 Neighboring gene uncharacterized LOC132346803 Neighboring gene ankyrin repeat domain 10 Neighboring gene uncharacterized LOC112449091 Neighboring gene uncharacterized LOC112449092

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC137370

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine--tRNA ligase, mitochondrial
    Names
    cysRS
    cysteine--tRNA ligase, mitochondrial-like
    cysteinyl-tRNA synthetase 2, mitochondrial (putative)
    cysteinyl-tRNA synthetase, mitochondrial
    probable cysteinyl-tRNA synthetase, mitochondrial
    NP_001039409.1
    XP_010809278.1
    XP_024855567.1
    XP_024855569.1
    XP_024855570.2
    XP_059747973.1
    XP_059747974.1
    XP_059747975.1
    XP_059747976.1
    XP_059747977.1
    XP_059747978.1
    XP_059747979.1
    XP_059747980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045944.2 → NP_001039409.1  cysteine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001039409.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112654
      UniProtKB/Swiss-Prot
      Q2KIF8
      UniProtKB/TrEMBL
      A0AAA9SEB2
      Related
      ENSBTAP00070014013.1, ENSBTAT00070023668.1
      Conserved Domains (2) summary
      cd00672
      Location:45 → 348
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      COG0215
      Location:45 → 544
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      85239190..85268251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059891995.1 → XP_059747978.1  cysteine--tRNA ligase, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A0AAA9SEB2

    2. XM_059891997.1 → XP_059747980.1  cysteine--tRNA ligase, mitochondrial isoform X12

    3. XM_059891994.1 → XP_059747977.1  cysteine--tRNA ligase, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0AAA9SEB2

    4. XM_059891996.1 → XP_059747979.1  cysteine--tRNA ligase, mitochondrial isoform X10

    5. XM_059891992.1 → XP_059747975.1  cysteine--tRNA ligase, mitochondrial isoform X3

    6. XM_059891991.1 → XP_059747974.1  cysteine--tRNA ligase, mitochondrial isoform X2

    7. XM_059891990.1 → XP_059747973.1  cysteine--tRNA ligase, mitochondrial isoform X1

    8. XM_024999802.2 → XP_024855570.2  cysteine--tRNA ligase, mitochondrial isoform X4

    9. XM_024999799.2 → XP_024855567.1  cysteine--tRNA ligase, mitochondrial isoform X7

      UniProtKB/TrEMBL
      A0A3Q1NB71, A0AAA9SEB2
      Related
      ENSBTAP00070014041.1, ENSBTAT00070023703.1
      Conserved Domains (1) summary
      cl27478
      Location:27 → 535
      tRNA-synt_1e; tRNA synthetases class I (C) catalytic domain

    10. XM_024999801.2 → XP_024855569.1  cysteine--tRNA ligase, mitochondrial isoform X9

      Conserved Domains (1) summary
      cl27478
      Location:53 → 462
      tRNA-synt_1e; tRNA synthetases class I (C) catalytic domain

    11. XM_010810976.4 → XP_010809278.1  cysteine--tRNA ligase, mitochondrial isoform X11

      Conserved Domains (2) summary
      COG0215
      Location:20 → 432
      CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl00015
      Location:20 → 245
      nt_trans; nucleotidyl transferase superfamily

    12. XM_059891993.1 → XP_059747976.1  cysteine--tRNA ligase, mitochondrial isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KIF8.1 GenPept UniProtKB/Swiss-Prot:Q2KIF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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