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    GPSM2 G protein signaling modulator 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 513654, updated on 30-Jan-2025

    Summary

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    Official Symbol
    GPSM2provided by VGNC
    Official Full Name
    G protein signaling modulator 2provided by VGNC
    Primary source
    VGNC:VGNC:29615
    See related
    BGD:BT22990; EnsemblRapid:ENSBTAG00070013169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GPSM2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (34431970..34518783, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 47 Neighboring gene chloride channel CLIC like 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene AKNA domain containing 1 Neighboring gene syntaxin binding protein 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene fibronectin type III domain containing 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein-signaling modulator 2
    Names
    G-protein signaling modulator 2 (AGS3-like, C. elegans)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192355.1 → NP_001179284.1  G-protein-signaling modulator 2

      Status: VALIDATED

      Source sequence(s)
      DN534428, DV927259, DV931627, DY113380, EH205894, EV627778
      UniProtKB/TrEMBL
      A0AAA9SM38, E1BIX7
      Related
      ENSBTAP00070018133.1, ENSBTAT00070029943.1
      Conserved Domains (5) summary
      smart00390
      Location:595 → 617
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:65 → 319
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:490 → 511
      GoLoco; GoLoco motif
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      34431970..34518783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059883900.1 → XP_059739883.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SM38, E1BIX7

    2. XM_010803163.4 → XP_010801465.1  G-protein-signaling modulator 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SM38
      Related
      ENSBTAP00070018110.1, ENSBTAT00070029883.1
      Conserved Domains (6) summary
      smart00390
      Location:470 → 492
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      sd00006
      Location:224 → 251
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:224 → 255
      TPR_1; Tetratricopeptide repeat
      pfam02188
      Location:526 → 547
      GoLoco; GoLoco motif
      pfam13176
      Location:265 → 299
      TPR_7; Tetratricopeptide repeat
      pfam13424
      Location:224 → 295
      TPR_12; Tetratricopeptide repeat

    3. XM_024988365.2 → XP_024844133.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SM38, E1BIX7
      Conserved Domains (5) summary
      smart00390
      Location:595 → 617
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:65 → 319
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:490 → 511
      GoLoco; GoLoco motif
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat

    4. XM_059883898.1 → XP_059739881.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SM38, E1BIX7

    5. XM_024988370.2 → XP_024844138.1  G-protein-signaling modulator 2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9SM38, E1BIX7
      Conserved Domains (5) summary
      smart00390
      Location:595 → 617
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      COG0457
      Location:65 → 319
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:243 → 270
      TPR; TPR repeat [structural motif]
      pfam02188
      Location:490 → 511
      GoLoco; GoLoco motif
      pfam13424
      Location:243 → 314
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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