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    DTNA dystrobrevin alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 541153, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DTNAprovided by VGNC
    Official Full Name
    dystrobrevin alphaprovided by VGNC
    Primary source
    VGNC:VGNC:28231
    See related
    BGD:BT19082; Ensembl:ENSBTAG00000012307
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DTNA in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (22130553..22581674, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene microtubule associated protein RP/EB family member 2 Neighboring gene uncharacterized LOC112444208 Neighboring gene uncharacterized LOC132343763 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112444199 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene protein maestro-like Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystrobrevin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076260.2 → NP_001069728.2  dystrobrevin alpha

      See identical proteins and their annotated locations for NP_001069728.2

      Status: INFERRED

      Source sequence(s)
      NKLS02000024
      UniProtKB/TrEMBL
      A0A3Q1NLH2
      Related
      ENSBTAP00000073257.1, ENSBTAT00000067408.2
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      pfam13874
      Location:470 → 553
      Nup54; Nucleoporin complex subunit 54

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22130553..22581674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024984389.2 → XP_024840157.1  dystrobrevin alpha isoform X14

      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:406 → 584
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. XM_024984390.2 → XP_024840158.1  dystrobrevin alpha isoform X14

      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:406 → 584
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    3. XM_005224027.5 → XP_005224084.1  dystrobrevin alpha isoform X10

      See identical proteins and their annotated locations for XP_005224084.1

      UniProtKB/TrEMBL
      A0A3Q1MQP6
      Related
      ENSBTAP00000072095.1, ENSBTAT00000084710.2
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:406 → 584
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    4. XM_010818729.4 → XP_010817031.1  dystrobrevin alpha isoform X13

      See identical proteins and their annotated locations for XP_010817031.1

      UniProtKB/TrEMBL
      A0A3Q1M823
      Related
      ENSBTAP00000070026.2, ENSBTAT00000085153.2
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam11068
      Location:414 → 502
      YlqD; YlqD protein
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:328 → 497
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_010818728.4 → XP_010817030.1  dystrobrevin alpha isoform X12

      See identical proteins and their annotated locations for XP_010817030.1

      UniProtKB/TrEMBL
      A0AAA9TEB9
      Related
      ENSBTAP00000095250.1, ENSBTAT00000132676.1
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:432 → 610
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:442 → 512
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    6. XM_059880981.1 → XP_059736964.1  dystrobrevin alpha isoform X3

    7. XM_059880985.1 → XP_059736968.1  dystrobrevin alpha isoform X8

    8. XM_010818727.4 → XP_010817029.1  dystrobrevin alpha isoform X7

      See identical proteins and their annotated locations for XP_010817029.1

      Conserved Domains (3) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam11068
      Location:471 → 559
      YlqD; YlqD protein
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    9. XM_015460061.3 → XP_015315547.1  dystrobrevin alpha isoform X11

      UniProtKB/TrEMBL
      A0AAA9TNH2
      Related
      ENSBTAP00000098800.1, ENSBTAT00000093389.1
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      pfam13874
      Location:440 → 523
      Nup54; Nucleoporin complex subunit 54

    10. XM_059880980.1 → XP_059736963.1  dystrobrevin alpha isoform X2

    11. XM_010818726.4 → XP_010817028.1  dystrobrevin alpha isoform X6

      See identical proteins and their annotated locations for XP_010817028.1

      UniProtKB/TrEMBL
      A0A3Q1MGW6
      Related
      ENSBTAP00000068279.2, ENSBTAT00000079620.2
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:493 → 671
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:503 → 573
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    12. XM_059880982.1 → XP_059736965.1  dystrobrevin alpha isoform X4

    13. XM_059880979.1 → XP_059736962.1  dystrobrevin alpha isoform X1

    14. XM_024984386.2 → XP_024840154.1  dystrobrevin alpha isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MGW6
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:493 → 671
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:503 → 573
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    15. XM_024984387.2 → XP_024840155.1  dystrobrevin alpha isoform X9

      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:462 → 640
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:472 → 542
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    16. XM_024984391.2 → XP_024840159.1  dystrobrevin alpha isoform X14

      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:406 → 584
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    17. XM_059880983.1 → XP_059736966.1  dystrobrevin alpha isoform X4

    18. XM_059880984.1 → XP_059736967.1  dystrobrevin alpha isoform X5

    19. XM_024984397.2 → XP_024840165.1  dystrobrevin alpha isoform X16

      UniProtKB/TrEMBL
      A0A3Q1LUN3
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:355 → 497
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    20. XM_024984395.2 → XP_024840163.1  dystrobrevin alpha isoform X16

      UniProtKB/TrEMBL
      A0A3Q1LUN3
      Related
      ENSBTAP00000058945.2, ENSBTAT00000082613.2
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:355 → 497
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    21. XM_024984394.2 → XP_024840162.1  dystrobrevin alpha isoform X15

      UniProtKB/TrEMBL
      A0A3Q1LUN3
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:410 → 556
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28419
      Location:473 → 543
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    22. XM_005224035.5 → XP_005224092.1  dystrobrevin alpha isoform X16

      See identical proteins and their annotated locations for XP_005224092.1

      UniProtKB/TrEMBL
      A0A3Q1LUN3
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:355 → 497
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    23. XM_024984398.2 → XP_024840166.1  dystrobrevin alpha isoform X16

      UniProtKB/TrEMBL
      A0A3Q1LUN3
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl25732
      Location:355 → 497
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    24. XM_005224038.5 → XP_005224095.1  dystrobrevin alpha isoform X17

      See identical proteins and their annotated locations for XP_005224095.1

      UniProtKB/TrEMBL
      Q17QL2
      Related
      ENSBTAP00000045669.2, ENSBTAT00000048673.3
      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    Nucleotide Protein Strain
    Heading Accession and Version

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