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    DHX57 DExH-box helicase 57 [ Bos taurus (domestic cattle) ]

    Gene ID: 540993, updated on 30-Jan-2025

    Summary

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    Official Symbol
    DHX57provided by VGNC
    Official Full Name
    DExH-box helicase 57provided by VGNC
    Primary source
    VGNC:VGNC:28057
    See related
    BGD:BT10262; EnsemblRapid:ENSBTAG00070023328
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DHX57 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (21145280..21205639, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat protein 39B-like Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene uncharacterized LOC132346555 Neighboring gene MORN repeat containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative ATP-dependent RNA helicase DHX57
    Names
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
    DEAH-box helicase 57
    NP_001192980.1
    XP_005212723.1
    XP_005212724.1
    XP_024854845.1
    XP_059747428.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206051.3 → NP_001192980.1  putative ATP-dependent RNA helicase DHX57

      See identical proteins and their annotated locations for NP_001192980.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      F1N1A2
      Related
      ENSBTAP00070031502.1, ENSBTAT00070052530.1
      Conserved Domains (8) summary
      smart00356
      Location:298 → 318
      ZnF_C3H1; zinc finger
      smart00487
      Location:549 → 726
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:1039 → 1121
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:557 → 699
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd14317
      Location:176 → 213
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam00271
      Location:828 → 964
      Helicase_C; Helicase conserved C-terminal domain
      pfam05773
      Location:238 → 413
      RWD; RWD domain
      pfam07717
      Location:1160 → 1307
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21145280..21205639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999077.2 → XP_024854845.1  putative ATP-dependent RNA helicase DHX57 isoform X2

      UniProtKB/TrEMBL
      F1N1A2
      Conserved Domains (3) summary
      COG1643
      Location:495 → 1371
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd14317
      Location:175 → 212
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam05773
      Location:240 → 413
      RWD; RWD domain

    2. XM_005212666.5 → XP_005212723.1  putative ATP-dependent RNA helicase DHX57 isoform X1

      See identical proteins and their annotated locations for XP_005212723.1

      UniProtKB/TrEMBL
      F1N1A2
      Conserved Domains (8) summary
      smart00356
      Location:298 → 318
      ZnF_C3H1; zinc finger
      smart00487
      Location:549 → 726
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:1039 → 1121
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:557 → 699
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd14317
      Location:176 → 213
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam00271
      Location:828 → 964
      Helicase_C; Helicase conserved C-terminal domain
      pfam05773
      Location:238 → 413
      RWD; RWD domain
      pfam07717
      Location:1160 → 1307
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. XM_005212667.5 → XP_005212724.1  putative ATP-dependent RNA helicase DHX57 isoform X1

      See identical proteins and their annotated locations for XP_005212724.1

      UniProtKB/TrEMBL
      F1N1A2
      Conserved Domains (8) summary
      smart00356
      Location:298 → 318
      ZnF_C3H1; zinc finger
      smart00487
      Location:549 → 726
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:1039 → 1121
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:557 → 699
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd14317
      Location:176 → 213
      UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
      pfam00271
      Location:828 → 964
      Helicase_C; Helicase conserved C-terminal domain
      pfam05773
      Location:238 → 413
      RWD; RWD domain
      pfam07717
      Location:1160 → 1307
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    4. XM_059891445.1 → XP_059747428.1  putative ATP-dependent RNA helicase DHX57 isoform X3

      UniProtKB/TrEMBL
      A0AAA9T2M0, A0AAA9TJM0
      Related
      ENSBTAP00070031493.1, ENSBTAT00070052515.1

    RNA

    1. XR_009496295.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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