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    CDK1 cyclin dependent kinase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281061, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CDK1provided by VGNC
    Official Full Name
    cyclin dependent kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:27115
    See related
    BGD:BT30042; Ensembl:ENSBTAG00000010109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CDC2
    Orthologs
    human mouse all
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    Genomic context

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    See CDK1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (16488151..16539563)

    Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene ankyrin 3 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene U6 spliceosomal RNA Neighboring gene ferritin heavy chain-like Neighboring gene uncharacterized LOC132344129 Neighboring gene Rho related BTB domain containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of cDNAs encoding bovine cyclin B and Cdk1/Cdc2. Yang L, et al. Gene, 1994 Apr 20. PMID 8163203
    2. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin. Matou-Nasri S, et al. Int J Oncol, 2009 Oct. PMID 19724912
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
      Title: Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134454

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 1
    Names
    cell division control protein 2 homolog
    cell division cycle 2, G1 to S and G2 to M
    cell division protein kinase 1
    p34 protein kinase
    NP_776441.1
    XP_005226354.1
    XP_005226356.1
    XP_010818803.1
    XP_024842276.1
    XP_059738393.1
    XP_059738394.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174016.2 → NP_776441.1  cyclin-dependent kinase 1

      See identical proteins and their annotated locations for NP_776441.1

      Status: PROVISIONAL

      Source sequence(s)
      L26547
      UniProtKB/TrEMBL
      A0AAA9TH51
      Related
      ENSBTAP00000013337.2, ENSBTAT00000013337.4
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 293
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07861
      Location:3 → 287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      16488151..16539563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226297.5 → XP_005226354.1  cyclin-dependent kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005226354.1

      UniProtKB/Swiss-Prot
      P48734, Q2YDM6
      UniProtKB/TrEMBL
      A0AAA9TH51
      Conserved Domains (1) summary
      cd07861
      Location:3 → 287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

    2. XM_010820501.4 → XP_010818803.1  cyclin-dependent kinase 1 isoform X3

      See identical proteins and their annotated locations for XP_010818803.1

      UniProtKB/TrEMBL
      A0AAA9TH51
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 267
      PLN00009; cyclin-dependent kinase A; Provisional
      cl21453
      Location:3 → 267
      PKc_like; Protein Kinases, catalytic domain

    3. XM_059882411.1 → XP_059738394.1  cyclin-dependent kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0AAA9TH51

    4. XM_005226299.4 → XP_005226356.1  cyclin-dependent kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005226356.1

      UniProtKB/Swiss-Prot
      P48734, Q2YDM6
      UniProtKB/TrEMBL
      A0AAA9TH51
      Conserved Domains (1) summary
      cd07861
      Location:3 → 287
      STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

    5. XM_024986508.2 → XP_024842276.1  cyclin-dependent kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MU67
      Related
      ENSBTAP00000058343.2, ENSBTAT00000076563.2
      Conserved Domains (1) summary
      cl21453
      Location:3 → 230
      PKc_like; Protein Kinases, catalytic domain

    6. XM_059882410.1 → XP_059738393.1  cyclin-dependent kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TH51
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48734.2 GenPept UniProtKB/Swiss-Prot:P48734

    Gene LinkOut

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