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    CERS2 ceramide synthase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 539223, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CERS2provided by VGNC
    Official Full Name
    ceramide synthase 2provided by VGNC
    Primary source
    VGNC:VGNC:27224
    See related
    BGD:BT26529; Ensembl:ENSBTAG00000000099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LASS2
    Orthologs
    human mouse all
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    Genomic context

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    See CERS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (19793120..19802016)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene prune exopolyphosphatase 1 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene cortexin domain containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126981

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ceramide synthase 2
    Names
    LAG1 homolog, ceramide synthase 2
    LAG1 longevity assurance 2
    LAG1 longevity assurance homolog 2
    sphingosine N-acyltransferase CERS2
    tumor metastasis-suppressor gene 1 protein
    very-long-chain ceramide synthase CERS2
    NP_001029839.1
    XP_005203977.1
    XP_024845379.1
    XP_024845380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034667.1 → NP_001029839.1  ceramide synthase 2

      See identical proteins and their annotated locations for NP_001029839.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103330
      UniProtKB/Swiss-Prot
      Q3ZBF8
      UniProtKB/TrEMBL
      A0AAF6YH00
      Related
      ENSBTAP00000000109.6, ENSBTAT00000000109.7
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19793120..19802016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024989612.2 → XP_024845380.1  ceramide synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZBF8
      UniProtKB/TrEMBL
      A0AAF6YH00
      Related
      ENSBTAP00000103338.1, ENSBTAT00000126401.1
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. XM_024989611.2 → XP_024845379.1  ceramide synthase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3ZBF8
      UniProtKB/TrEMBL
      A0AAF6YH00
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    3. XM_005203920.5 → XP_005203977.1  ceramide synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_005203977.1

      UniProtKB/Swiss-Prot
      Q3ZBF8
      UniProtKB/TrEMBL
      A0AAF6YH00
      Conserved Domains (2) summary
      smart00724
      Location:131 → 332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71 → 128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZBF8.1 GenPept UniProtKB/Swiss-Prot:Q3ZBF8

    Gene LinkOut

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