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    HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 506001, updated on 1-Jan-2025

    Summary

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    Official Symbol
    HOGA1provided by VGNC
    Official Full Name
    4-hydroxy-2-oxoglutarate aldolase 1provided by VGNC
    Primary source
    VGNC:VGNC:29900
    See related
    Ensembl:ENSBTAG00000012721
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NPL2; DHDPSL; C10orf65
    Orthologs
    human mouse all
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    Genomic context

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    See HOGA1 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (18771726..18793257)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 1 Neighboring gene ankyrin repeat domain 2 Neighboring gene chromosome 26 C10orf62 homolog Neighboring gene MORN repeat containing 4 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Use of a novel microtitration protocol to obtain diffraction-quality crystals of 4-hydroxy-2-oxoglutarate aldolase from Bos taurus. Huang A, et al. Acta Crystallogr F Struct Biol Commun, 2014 Nov. PMID 25372828, Free PMC Article
    2. 2-Keto-4-hydroxyglutarate aldolase: purification and characterization of the homogeneous enzyme from bovine kidney. Dekker EE, et al. J Biol Chem, 1992 May 25. PMID 1587831
    3. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. Riedel TJ, et al. PLoS One, 2011. PMID 21998747, Free PMC Article
    4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Native HOGA was purified from bovine kidney using a novel microtitration protocol to obtain diffraction-quality crystals.
      Title: Use of a novel microtitration protocol to obtain diffraction-quality crystals of 4-hydroxy-2-oxoglutarate aldolase from Bos taurus.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140473

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables (R,S)-4-hydroxy-2-oxoglutarate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glyoxylate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial
    Names
    DHDPS-like protein
    N-acetylneuraminate pyruvate lyase 2 (putative)
    dihydrodipicolinate synthase-like, mitochondrial
    probable 2-keto-4-hydroxyglutarate aldolase
    probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
    probable KHG-aldolase
    NP_001068705.1
    XP_024841297.1
    XP_024841298.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075237.1 → NP_001068705.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001068705.1

      Status: PROVISIONAL

      Source sequence(s)
      BT026547
      UniProtKB/TrEMBL
      A0AAA9RW02
      Conserved Domains (1) summary
      cd00408
      Location:38 → 318
      DHDPS-like; Dihydrodipicolinate synthase family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      18771726..18793257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985529.2 → XP_024841297.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q0P5I5, Q0V7M3
      UniProtKB/TrEMBL
      A0AAA9RW02
      Related
      ENSBTAP00000016909.4, ENSBTAT00000016909.6
      Conserved Domains (1) summary
      cd00408
      Location:38 → 318
      DHDPS-like; Dihydrodipicolinate synthase family

    2. XM_024985530.2 → XP_024841298.1  4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd00408
      Location:5 → 253
      DHDPS-like; Dihydrodipicolinate synthase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P5I5.1 GenPept UniProtKB/Swiss-Prot:Q0P5I5

    Gene LinkOut

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