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    IRX3 iroquois homeobox 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 540417, updated on 30-Jan-2025

    Summary

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    Official Symbol
    IRX3provided by VGNC
    Official Full Name
    iroquois homeobox 3provided by VGNC
    Primary source
    VGNC:VGNC:30287
    See related
    EnsemblRapid:ENSBTAG00070020166
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IRX3 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (22615021..22618040, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC132342808 Neighboring gene mitochondrial import inner membrane translocase subunit Tim29-like Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC104974837

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148829

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iroquois-class homeodomain protein IRX-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104996.2 → NP_001098466.1  iroquois-class homeodomain protein IRX-3

      See identical proteins and their annotated locations for NP_001098466.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133453
      UniProtKB/TrEMBL
      A0AAA9S1P3, A2VDX5, F1MZH2
      Related
      ENSBTAP00070027315.1, ENSBTAT00070045486.1
      Conserved Domains (2) summary
      smart00548
      Location:344 → 359
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22615021..22618040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024978462.2 → XP_024834230.1  iroquois-class homeodomain protein IRX-3 isoform X3

      UniProtKB/TrEMBL
      A0AAA9S1P3
      Related
      ENSBTAP00070027328.1, ENSBTAT00070045529.1
      Conserved Domains (2) summary
      smart00548
      Location:344 → 359
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain

    2. XM_024978463.2 → XP_024834231.1  iroquois-class homeodomain protein IRX-3 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MVT3, A0AAA9SFH4
      Related
      ENSBTAP00070027323.1, ENSBTAT00070045508.1
      Conserved Domains (2) summary
      smart00548
      Location:344 → 359
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain

    3. XM_024978460.2 → XP_024834228.1  iroquois-class homeodomain protein IRX-3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFH4
      Conserved Domains (2) summary
      smart00548
      Location:344 → 359
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain

    4. XM_024978459.2 → XP_024834227.1  iroquois-class homeodomain protein IRX-3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SFH4
      Conserved Domains (2) summary
      smart00548
      Location:344 → 359
      IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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