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    DSG1 desmoglein 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281131, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DSG1provided by VGNC
    Official Full Name
    desmoglein 1provided by VGNC
    Primary source
    VGNC:VGNC:28220
    See related
    BGD:BT10920; Ensembl:ENSBTAG00000013831
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See DSG1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (25777696..25821619, complement)

    Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene desmoglein 3 Neighboring gene desmoglein 4 Neighboring gene uncharacterized LOC101904557 Neighboring gene desmocollin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. Puttagunta S, et al. J Biol Chem, 1994 Jan 21. PMID 8294446
    2. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Koch PJ, et al. Eur J Cell Biol, 1990 Oct. PMID 1706270
    3. Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules. Goodwin L, et al. Biochem Biophys Res Commun, 1990 Dec 31. PMID 1702628
    4. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. Mathur M, et al. J Biol Chem, 1994 May 13. PMID 8188687
    5. Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene. Koch PJ, et al. Eur J Cell Biol, 1991 Aug. PMID 1935985

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables gamma-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    desmoglein-1
    Names
    DG1
    DGI
    desmosomal glycoprotein 1
    pemphigus foliaceus antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174045.1 → NP_776470.1  desmoglein-1 precursor

      See identical proteins and their annotated locations for NP_776470.1

      Status: PROVISIONAL

      Source sequence(s)
      X58466
      UniProtKB/Swiss-Prot
      Q03763, Q9TS15
      UniProtKB/TrEMBL
      F1MIW8
      Related
      ENSBTAP00000018382.5, ENSBTAT00000018382.6
      Conserved Domains (4) summary
      cd11304
      Location:161 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:73 → 155
      CA; Cadherin repeats
      pfam00028
      Location:274 → 360
      Cadherin; Cadherin domain
      pfam01049
      Location:650 → 765
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25777696..25821619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03763.1 GenPept UniProtKB/Swiss-Prot:Q03763

    Gene LinkOut

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