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    GCH1 GTP cyclohydrolase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 286815, updated on 27-Dec-2024

    Summary

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    Official Symbol
    GCH1provided by VGNC
    Official Full Name
    GTP cyclohydrolase 1provided by VGNC
    Primary source
    VGNC:VGNC:29286
    See related
    BGD:BT25234; Ensembl:ENSBTAG00000040151
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GCH1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (67338564..67400557, complement)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4A Neighboring gene microRNA mir-2292 Neighboring gene palmitoyl-protein thioesterase 1-like Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene suppressor of cytokine signaling 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP cyclohydrolase I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP cyclohydrolase 1
    Names
    GTP cyclohydrolase 1 (dopa-responsive dystonia)
    XP_002690995.1
    XP_015328698.1
    XP_059746855.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      67338564..67400557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002690949.7 → XP_002690995.1  GTP cyclohydrolase 1 isoform X1

      See identical proteins and their annotated locations for XP_002690995.1

      UniProtKB/TrEMBL
      A0AAA9SF01, F1MZ14
      Related
      ENSBTAP00000081007.1, ENSBTAT00000102569.1
      Conserved Domains (1) summary
      cd00642
      Location:65 → 249
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

    2. XM_015473212.3 → XP_015328698.1  GTP cyclohydrolase 1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T909
      Conserved Domains (1) summary
      cl00263
      Location:65 → 179
      TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...

    3. XM_059890872.1 → XP_059746855.1  GTP cyclohydrolase 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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