ASS1 argininosuccinate synthase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ASS1provided by VGNC
Official Full Name: argininosuccinate synthase 1provided by VGNC
Primary source: VGNC:VGNC:26224
See related: BGD:BT12411; Ensembl:ENSBTAG00000020747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CN; ASS
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (100770227..100822223)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

calcium-dependent phosphorylation of argininosuccinate synthase Ser-328 is mediated by PKCalpha
Title: Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
These results represent the first demonstration that vascular endothelial nitric oxide production can be regulated by dynamic argininosuccinate synthase phosphorylation.
Title: Phosphorylation of argininosuccinate synthase by protein kinase A.
In endothelial cells TNF-alpha coordinately downregulates nitric oxide synthase (eNOS) and argininosuccinate synthase expression, resulting in a severely impaired citrulline-NO cycle.
Title: Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells.
dose-dependent reduction of ASS as a result of siRNA treatment corresponded to diminished capacity to produce NO, despite saturating levels of arginine in the medium; reduced expression of ASS resulted in loss of viability due to apoptosis
Title: Argininosuccinate synthase expression is required to maintain nitric oxide production and cell viability in aortic endothelial cells.
the function of the extended 5'-UTRs of AS mRNA was investigated
Title: Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame.

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General gene information

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Markers

D9S1956 (e-PCR)
- UniSTS:81426

Ass1 (e-PCR), detects polymorphism
- UniSTS:506742

D9S2057 (e-PCR)
- UniSTS:46005

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables argininosuccinate synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in argininosuccinate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: argininosuccinate synthase

Names: arginino succinate synthetase; argininosuccinate synthetase 1; citrulline--aspartate ligase; citrullinemia; mutant arginino succinate synthetase

NP_776317.1

EC 6.3.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.