PGR progesterone receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PGRprovided by VGNC
Official Full Name: progesterone receptorprovided by VGNC
Primary source: VGNC:VGNC:106863
See related: EnsemblRapid:ENSBTAG00070015321
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	15	NC_037342.1 (7854066..7967424)

Chromosome 15 - NC_037342.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-375 represses oocyte in vitro maturation at least partially through targeting ADAMTS1 and PGR in cumulus cells.
Title: MicroRNA-375 regulates oocyte in vitro maturation by targeting ADAMTS1 and PGR in bovine cumulus cells.
The data obtained indicate that the higher promoter methylation of the PGRA isoform could be a mechanism for regulation of PGRA inhibitory activity against PGRB and, in this way, methylation may influence the regulation of progesterone action in the corpora lutea and endometrium.
Title: Methylation of progesterone receptor isoform A and B promoters in the reproductive system of cows.
PGRB mRNA level was highest on Days 2-5 of the oestrous cycle, decreased over the next few days and increased again slightly on Days 17-20. The profile of PGRA mRNA levels was similar to that of PGRB throughout the oestrous cycle. During pregnancy, PGRB mRNA was at its lowest level during Weeks 3-5 and highest during Weeks 6-12.
Title: Cloning and expression of progesterone receptor isoforms A and B in bovine corpus luteum.
the LH surge induces expression of PR by granulosa cells and withdrawal from the cell cycle, and these events promote resistance to apoptosis.
Title: Progesterone receptor and the cell cycle modulate apoptosis in granulosa cells.
Data suggest that expression of nuclear PR (progesterone receptor) and PGRMC (progesterone receptor membrane components 1/2) vary with region of oviduct. Expression of PR, PGRMC1, and PGRMC2 are not affected by pregnancy or presence of corpus luteum.
Title: Expression of nuclear progesterone receptor and progesterone receptor membrane components 1 and 2 in the oviduct of cyclic and pregnant cows during the post-ovulation period.
analysis of expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy
Title: Expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy.
These results showed for the first time that 2 polymorphisms in the progesterone receptor (PGR) gene were associated with superovulation traits and indicated that it can be used as a predictor for superovulation in Chinese Holstein cows.
Title: Association analysis between variants in bovine progesterone receptor gene and superovulation traits in Chinese Holstein cows.
progesterone receptor has a role in regulating luteal and endothelial cell function in the bovine corpus luteum, especially at the early luteal stage as an autocrine/paracrine regulator
Title: Changes in the levels of progesterone receptor mRNA and protein in the bovine corpus luteum during the estrous cycle.
there are different levels of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo
Title: Expression and localization of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in the bovine oviduct in vivo and in vitro.
the PGR single nucleotide polymorphisms could be used in marker-assisted selection breeding programs in Holstein dairy cattle
Title: Short communication: Effects of the progesterone receptor variants on fertility traits in cattle.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

PGR (e-PCR)
- UniSTS:253996

PGR-1 (e-PCR)
- UniSTS:253996

BZ939858 (e-PCR)
- UniSTS:476287

BARC0082 (e-PCR)
- UniSTS:277894

PGR (e-PCR)
- UniSTS:253938

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables estrogen response element binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: progesterone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205356.1 → NP_001192285.1 progesterone receptor

Status: PROVISIONAL

Source sequence(s)

AJ557823, AY656812, NKLS02000015

UniProtKB/TrEMBL

F1N712

Related

ENSBTAP00070020465.1, ENSBTAT00070034665.1

Conserved Domains (3) summary

cd07074
Location:666 → 913

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cd07172
Location:543 → 620

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 544

Prog_receptor; Progesterone receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

Range

7854066..7967424

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025002034.2 → XP_024857802.1 progesterone receptor isoform X1

UniProtKB/TrEMBL

F1N712

Conserved Domains (3) summary

cd07074
Location:628 → 875

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

pfam02161
Location:1 → 545

Prog_receptor; Progesterone receptor

cl02596
Location:544 → 579

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_025002035.2 → XP_024857803.1 progesterone receptor isoform X2

UniProtKB/TrEMBL

Q863K6

Conserved Domains (3) summary

cd07074
Location:159 → 406

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cd07172
Location:36 → 113

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:19 → 37

Prog_receptor; Progesterone receptor