SFTPD surfactant protein D [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: SFTPD
Gene description: surfactant protein D
See related: BGD:BT11867; Ensembl:ENSBTAG00000046421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: SP-D; COLEC7
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	28	NC_037355.1 (35610572..35620590)

Chromosome 28 - NC_037355.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevation of SP-D is found in bronchoalveolar lavage fluid from inoculated lobes of calves infected with bovine adenovirus type 3.
Title: Development of enzyme-linked immunosorbent assay for bovine surfactant protein D in bronchoalveolar lavage fluid.
The bSP-D gene has 9 exons spanning about 10.5 kb on chromosome 28 at position q1.8. The 5'-upstream sequence has cis-regulatory elements. It has 2 polymorphisms in the carbohydrate recognition domain (242 Glu/Val & 268 Ala/Gly).
Title: Genomic and molecular characterization of bovine surfactant protein D (SP-D).

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pulmonary surfactant-associated protein D

Names: PSP-D; lung surfactant protein D; surfactant, pulmonary-associated protein D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181026.2 → NP_851369.1 pulmonary surfactant-associated protein D precursor

See identical proteins and their annotated locations for NP_851369.1

Status: PROVISIONAL

Source sequence(s)

X75911

UniProtKB/TrEMBL

A0A3Q1LV99

Related

ENSBTAP00000008579.5, ENSBTAT00000008579.7

Conserved Domains (3) summary

pfam01391
Location:145 → 204

Collagen; Collagen triple helix repeat (20 copies)

pfam09006
Location:218 → 263

Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization

cl02432
Location:256 → 369

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain