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    TCOF1 treacle ribosome biogenesis factor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 513591, updated on 1-Jan-2025

    Summary

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    Official Symbol
    TCOF1provided by VGNC
    Official Full Name
    treacle ribosome biogenesis factor 1provided by VGNC
    Primary source
    VGNC:VGNC:35700
    See related
    BGD:BT23557; Ensembl:ENSBTAG00000015224
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TCOF1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (61708244..61746781)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent protein kinase II alpha Neighboring gene arylsulfatase family member I Neighboring gene uncharacterized LOC107132649 Neighboring gene CD74 molecule Neighboring gene ribosomal protein S14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleolar large rRNA transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    treacle protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      61708244..61746781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002689293.7 → XP_002689339.2  treacle protein isoform X1

      See identical proteins and their annotated locations for XP_002689339.2

      UniProtKB/TrEMBL
      A6QP77, E1BHU1
      Related
      ENSBTAP00000020259.5, ENSBTAT00000020259.6
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:319 → 840
      Treacle; Treacher Collins syndrome protein Treacle

    2. XM_010807517.4 → XP_010805819.1  treacle protein isoform X1

      See identical proteins and their annotated locations for XP_010805819.1

      UniProtKB/TrEMBL
      A6QP77, E1BHU1
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:319 → 840
      Treacle; Treacher Collins syndrome protein Treacle

    3. XM_005209634.5 → XP_005209691.1  treacle protein isoform X3

      See identical proteins and their annotated locations for XP_005209691.1

      UniProtKB/TrEMBL
      A0A3Q1LFY9, A6QP77
      Related
      ENSBTAP00000057207.1, ENSBTAT00000072043.2
      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:319 → 840
      Treacle; Treacher Collins syndrome protein Treacle

    4. XM_059888793.1 → XP_059744776.1  treacle protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LX56, A6QP77
      Related
      ENSBTAP00000062051.1, ENSBTAT00000070090.2

    5. XM_059888794.1 → XP_059744777.1  treacle protein isoform X4

    6. XM_024995260.2 → XP_024851028.1  treacle protein isoform X5

      Conserved Domains (2) summary
      smart00667
      Location:6 → 37
      LisH; Lissencephaly type-1-like homology motif
      pfam03546
      Location:319 → 840
      Treacle; Treacher Collins syndrome protein Treacle

    RNA

    1. XR_807937.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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