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    OAZ2 ornithine decarboxylase antizyme 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 524677, updated on 27-Dec-2024

    Summary

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    Official Symbol
    OAZ2provided by VGNC
    Official Full Name
    ornithine decarboxylase antizyme 2provided by VGNC
    Primary source
    VGNC:VGNC:32393
    See related
    Ensembl:ENSBTAG00000015806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See OAZ2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (45366519..45379630)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing O2 Neighboring gene uncharacterized LOC132346299 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene zinc finger protein 609 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene large ribosomal subunit protein eL22-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
    2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172576.2 → NP_001166047.1  ornithine decarboxylase antizyme 2 isoform 1

      See identical proteins and their annotated locations for NP_001166047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC149484, BC149845, CB461552, DN531747, EE350146
      UniProtKB/TrEMBL
      A6QQI3
      Related
      ENSBTAP00000042402.4, ENSBTAT00000044965.5
      Conserved Domains (1) summary
      pfam02100
      Location:100 → 181
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_001301322.1 → NP_001288251.1  ornithine decarboxylase antizyme 2 isoform 2

      See identical proteins and their annotated locations for NP_001288251.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      BC149845, CB461552, CO887362, DN531747, EE350146
      UniProtKB/TrEMBL
      A6QQI3
      Conserved Domains (1) summary
      pfam02100
      Location:97 → 180
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45366519..45379630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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