CASP3 caspase 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CASP3provided by VGNC
Official Full Name: caspase 3provided by VGNC
Primary source: VGNC:VGNC:26781
See related: BGD:BT10404; Ensembl:ENSBTAG00000015874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	27	NC_037354.1 (15047753..15072825, complement)

Chromosome 27 - NC_037354.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
Title: Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage.
Data suggest that Escherichia coli infections (here, administration of LPS) provokes luteolysis in diestrus, non-lactating cows and up-regulation of expression of caspase 3 in corpus luteum but has no effect on luteinization in the following cycle.
Title: Escherichia coli lipopolysaccharide administration transiently suppresses luteal structure and function in diestrous cows.
Treatment of mammary epithelial cells with serotonin 1B and serotonin 2A receptor antagonists increased caspase-3 activity.
Title: The bovine mammary gland expresses multiple functional isoforms of serotonin receptors.
the capacity for blastocysts to undergo further development is related to degree of group II caspase activity
Title: Relationship between group II caspase activity of bovine preimplantation embryos and capacity for hatching.
mRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method.
Title: mRNA expression of Bcl-2, Bax, caspase-3 and -7 cannot be used as a marker for apoptosis in bovine blastocysts.
Data suggest that activation of caspase-3 is likely involved in both spontaneous and induced apoptosis in bovine pre-implantation embryos.
Title: Active caspase-3 and ultrastructural evidence of apoptosis in spontaneous and induced cell death in bovine in vitro produced pre-implantation embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: caspase-3

Names: CASP-3; caspase 3, apoptosis-related cysteine peptidase

NP_001071308.1

EC 3.4.22.56

XP_010818547.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077840.1 → NP_001071308.1 caspase-3

See identical proteins and their annotated locations for NP_001071308.1

Status: PROVISIONAL

Source sequence(s)

BC123503

UniProtKB/Swiss-Prot

Q08DY9

UniProtKB/TrEMBL

A0AAA9THN7

Related

ENSBTAP00000021099.6, ENSBTAT00000021099.7

Conserved Domains (1) summary

smart00115
Location:37 → 275

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

Range

15047753..15072825 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010820245.4 → XP_010818547.1 caspase-3 isoform X1

UniProtKB/TrEMBL

A0AAA9THN7, F1MB04

Conserved Domains (1) summary

smart00115
Location:39 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues