U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ECA1 ER-type Ca2+-ATPase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837296, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ECA1
    Official Full Name
    ER-type Ca2+-ATPase 1
    Primary source
    TAIR:AT1G07810
    Locus tag
    AT1G07810
    See related
    Araport:AT1G07810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACA3; ARABIDOPSIS THALIANA ER-TYPE CA2+-ATPASE 1; ATECA1; ER-TYPE CA2+-ATPASE; ER-type Ca2+-ATPase 1; F24B9.9; F24B9_9
    Summary
    Encodes an ER-type Ca2+-pumping ATPase.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ECA1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (2416178..2420829)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene forkhead box protein G1 Neighboring gene pseudo Neighboring gene Histone superfamily protein Neighboring gene ribosomal protein L29 family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An A/ENTH domain-containing protein functions as an adaptor for clathrin-coated vesicles on the growing cell plate in Arabidopsis root cells. Song K, et al. Plant Physiol, 2012 Jul. PMID 22635117, Free PMC Article
    2. An endoplasmic reticulum-bound Ca(2+)/Mn(2+) pump, ECA1, supports plant growth and confers tolerance to Mn(2+) stress. Wu Z, et al. Plant Physiol, 2002 Sep. PMID 12226493, Free PMC Article
    3. MIZ1 regulates ECA1 to generate a slow, long-distance phloem-transmitted Ca(2+) signal essential for root water tracking in Arabidopsis. Shkolnik D, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 30012618, Free PMC Article
    4. ECA1 complements yeast mutants defective in Ca2+ pumps and encodes an endoplasmic reticulum-type Ca2+-ATPase in Arabidopsis thaliana. Liang F, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238019, Free PMC Article
    5. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the inhibition of ECA1 by MIZ1 changes the balance between cytosolic Ca(2+) influx and efflux and generates the cytosolic Ca(2+) signal required for water tracking.
      Title: MIZ1 regulates ECA1 to generate a slow, long-distance phloem-transmitted Ca(2+) signal essential for root water tracking in Arabidopsis.
    2. An AP180 amino-terminal homology/epsin amino-terminal homology domain-containing protein from Arabidopsis (Arabidopsis thaliana) is involved in clathrin-coated vesicle formation from the cell plate.
      Title: An A/ENTH domain-containing protein functions as an adaptor for clathrin-coated vesicles on the growing cell plate in Arabidopsis root cells.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_100655.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables P-type calcium transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular manganese ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within manganese ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to manganese ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ER-type Ca2+-ATPase 1
    NP_172259.1
    • ER-type Ca2+-ATPase 1 (ECA1); FUNCTIONS IN: calcium-transporting ATPase activity; INVOLVED IN: manganese ion transport, response to cadmium ion, cellular manganese ion homeostasis, calcium ion transport, response to manganese ion; LOCATED IN: endoplasmic reticulum, plasma membrane, endoplasmic reticulum membrane; EXPRESSED IN: guard cell, callus, cultured cell; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting (InterPro:IPR005782), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: endomembrane-type CA-ATPase 4 (TAIR:AT1G07670.1); Has 52947 Blast hits to 34771 proteins in 3297 species: Archae - 1117; Bacteria - 37251; Metazoa - 4506; Fungi - 2912; Plants - 2416; Viruses - 3; Other Eukaryotes - 4742 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2416178..2420829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100655.4 → NP_172259.1  ER-type Ca2+-ATPase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04987, P92939
      UniProtKB/TrEMBL
      A0A178W6B4
      Conserved Domains (1) summary
      cl21460
      Location:27 → 1042
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92939.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools