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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_012267.1 RefSeqGene
- Range
-
4742..70025
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_003502.4 → NP_003493.1 axin-1 isoform a
See identical proteins and their annotated locations for NP_003493.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
- Source sequence(s)
-
AC005202, AF009674, BC035872, DB460285, Z69667, Z99754
- Consensus CDS
-
CCDS10405.1
- UniProtKB/Swiss-Prot
- O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28
- UniProtKB/TrEMBL
- A0A0S2Z4M1, A0A0S2Z4R0
- Related
- ENSP00000262320.3, ENST00000262320.8
- Conserved Domains (4) summary
-
- cd08707
Location:89 → 209
- RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
- cd11582
Location:11 → 80
- Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
- pfam00778
Location:782 → 857
- DIX; DIX domain
- pfam08833
Location:464 → 520
- Axin_b-cat_bind; Axin beta-catenin binding domain
-
NM_181050.3 → NP_851393.1 axin-1 isoform b
See identical proteins and their annotated locations for NP_851393.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is shorter, compared to isoform a. An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
- Source sequence(s)
-
AC005202, BC035872, BC044648, DB460285, Z69667
- Consensus CDS
-
CCDS10406.1
- UniProtKB/TrEMBL
- A0A0S2Z4M1, A0A0S2Z4S3
- Related
- ENSP00000346935.3, ENST00000354866.7
- Conserved Domains (4) summary
-
- cd08707
Location:89 → 209
- RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
- cd11582
Location:11 → 80
- Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
- pfam00778
Location:746 → 821
- DIX; DIX domain
- pfam08833
Location:464 → 520
- Axin_b-cat_bind; Axin beta-catenin binding domain
RNA
-
NR_134879.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC005202, BC035872, KF615852