U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZAR1 HOPZ-ACTIVATED RESISTANCE 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824259, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZAR1
    Official Full Name
    HOPZ-ACTIVATED RESISTANCE 1
    Primary source
    TAIR:AT3G50950
    Locus tag
    AT3G50950
    See related
    Araport:AT3G50950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HOPZ-ACTIVATED RESISTANCE 1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZAR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (18935674..18938799)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cytochrome BC1 synthesi Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene thioredoxin domain PLP3A-like protein Neighboring gene dehydrin family protein Neighboring gene dehydrin xero 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Utilising natural diversity of kinases to rationally engineer interactions with the angiosperm immune receptor ZAR1. Diplock N, et al. Plant Cell Environ, 2023 Jul. PMID 37157998
    2. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling. Bi G, et al. Cell, 2021 Jun 24. PMID 33984278
    3. Resistosome and inflammasome: platforms mediating innate immunity. Xiong Y, et al. Curr Opin Plant Biol, 2020 Aug. PMID 32554225
    4. Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo. Hu M, et al. Mol Plant, 2020 May 4. PMID 32194243
    5. Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein. Lewis JD, et al. PLoS Genet, 2010 Apr 1. PMID 20368970, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Utilising natural diversity of kinases to rationally engineer interactions with the angiosperm immune receptor ZAR1.
      Title: Utilising natural diversity of kinases to rationally engineer interactions with the angiosperm immune receptor ZAR1.
    2. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling.
      Title: The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling.
    3. A natural diversity screen in Arabidopsis thaliana reveals determinants for HopZ1a recognition in the ZAR1-ZED1 immune complex.
      Title: A natural diversity screen in Arabidopsis thaliana reveals determinants for HopZ1a recognition in the ZAR1-ZED1 immune complex.
    4. Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo.
      Title: Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo.
    5. Resistosome and inflammasome: platforms mediating innate immunity.
      Title: Resistosome and inflammasome: platforms mediating innate immunity.
    6. NLRs SZE1 and SZE2 interact with HopZ1a and function together with ZED1 to change the intramolecular interactions of ZAR1, leading to its activation, which is critical for HopZ1a-triggered immunity
      Title: Two Arabidopsis Receptor-like Cytoplasmic Kinases SZE1 and SZE2 Associate with the ZAR1-ZED1 Complex and Are Required for Effector-Triggered Immunity.
    7. The Arabidopsis ZAR1 NLR protein requires the ZRK3 kinase to recognize the Pseudomonas syringae type III effector (T3E) HopF2a.
      Title: Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.
    8. ZAR1 role in high temperature-induced autoimmunity
      Title: Arabidopsis ZED1-related kinases mediate the temperature-sensitive intersection of immune response and growth homeostasis.
    9. This detailed analysis of the AtZAR1-AtZED1 protein complex provides a better understanding of the immune signaling hub controlled by AtZAR1.
      Title: Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions.
    10. The disruption of ZAR1 and AGB1 results in short basal cell and an apical cell with basal cell fate
      Title: The Arabidopsis Receptor Kinase ZAR1 Is Required for Zygote Asymmetric Division and Its Daughter Cell Fate.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_114955.4
    NM_180346.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    HOPZ-ACTIVATED RESISTANCE 1
    NP_190664.1
    • HOPZ-ACTIVATED RESISTANCE 1 (ZAR1); FUNCTIONS IN: ATP binding; INVOLVED IN: defense response, apoptosis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT5G43470.2); Has 15477 Blast hits to 13963 proteins in 472 species: Archae - 2; Bacteria - 362; Metazoa - 212; Fungi - 129; Plants - 14652; Viruses - 8; Other Eukaryotes - 112 (source: NCBI BLink).
    NP_850677.1
    • HOPZ-ACTIVATED RESISTANCE 1 (ZAR1); FUNCTIONS IN: ATP binding; INVOLVED IN: defense response, apoptosis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (CC-NBS-LRR class) family (TAIR:AT5G43470.2); Has 15477 Blast hits to 13963 proteins in 472 species: Archae - 2; Bacteria - 362; Metazoa - 212; Fungi - 129; Plants - 14652; Viruses - 8; Other Eukaryotes - 112 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18935674..18938799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114955.4 → NP_190664.1  HOPZ-ACTIVATED RESISTANCE 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUW7, Q38834, Q9SVK4
      UniProtKB/TrEMBL
      A0A178VBG3
      Conserved Domains (4) summary
      COG4886
      Location:465 → 747
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14798
      Location:3 → 127
      RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
      sd00033
      Location:561 → 587
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:163 → 410
      NB-ARC; NB-ARC domain

    2. NM_180346.1 → NP_850677.1  HOPZ-ACTIVATED RESISTANCE 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUW7, Q38834, Q9SVK4
      UniProtKB/TrEMBL
      A0A178VBG3
      Conserved Domains (4) summary
      COG4886
      Location:465 → 747
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14798
      Location:3 → 127
      RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
      sd00033
      Location:561 → 587
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:163 → 410
      NB-ARC; NB-ARC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38834.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.