APBA2 amyloid beta precursor protein binding family A member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: APBA2provided by HGNC
Official Full Name: amyloid beta precursor protein binding family A member 2provided by HGNC
Primary source: HGNC:HGNC:579
See related: Ensembl:ENSG00000034053 MIM:602712; AllianceGenome:HGNC:579
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]
Expression: Biased expression in brain (RPKM 16.8), spleen (RPKM 2.5) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q13.1

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (28885974..29118315)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (26662979..26895835)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (29131120..29410518)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.
Title: A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.
Using exome sequencing and QTL analysis, study identified seven genome-wide significant loci accounting for approximately one-third of total variance and two-thirds of genetic variance in exploratory locomotion (EL), a behavioral phenotype correlated with vulnerability to addiction, and found convergent evidence for a role of APBA2 in humans.
Title: Exploratory locomotion, a predictor of addiction vulnerability, is oligogenic in rats selected for this phenotype.
These results support the hypothesis that APBA2 gene expression in different areas of Alzheimer's patient's brains.
Title: Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients.
Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production.
Title: Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generation.
Aberrant MINT2 methylation in body fluids may predict peritoneal micrometastasis for gastric cancer (GC) patients, which is a potential poor prognostic factor in GC.
Title: Circulating methylated MINT2 promoter DNA is a potential poor prognostic factor in gastric cancer.
a significant difference was shown for APBA2 gene expression of peripheral lymphocytes between Chinese Han Tourette syndrome (TS) group and healthy controls idicating the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects
Title: Gene expression changes in peripheral blood from Chinese Han patients with Tourette syndrome.
Amyloid beta A4 precursor protein-binding family A member 2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and glucocorticoid receptor [alpha], paired box protein 5.
Title: Promoter characterization and genomic organization of the human X11β gene APBA2.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD.
Title: Copy number and sequence variants implicate APBA2 as an autism candidate gene.
APBA2 were genes activated in early endometrial endometrioid carcinoma (stages I-II).
Title: Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G63439 (e-PCR)
- UniSTS:140551

PMC156605P1 (e-PCR)
- UniSTS:271395

PMC156605P10 (e-PCR)
- UniSTS:271396

PMC156605P11 (e-PCR)
- UniSTS:271397

PMC156605P12 (e-PCR)
- UniSTS:271398

PMC156605P13 (e-PCR)
- UniSTS:271399

PMC156605P2 (e-PCR)
- UniSTS:271400

PMC156605P3 (e-PCR)
- UniSTS:271401

PMC156605P4 (e-PCR)
- UniSTS:271402

Apba2 (e-PCR), detects polymorphism
- UniSTS:141098

PMC156605P5 (e-PCR)
- UniSTS:271403

PMC156605P6 (e-PCR)
- UniSTS:271404

PMC156605P7 (e-PCR)
- UniSTS:271405

PMC156605P8 (e-PCR)
- UniSTS:271406

PMC156605P9 (e-PCR)
- UniSTS:271407

RH123618 (e-PCR)
- UniSTS:136037

D1S1425 (e-PCR)
- UniSTS:149621

WI-14097 (e-PCR)
- UniSTS:65160

RH119189 (e-PCR)
- UniSTS:138698

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amyloid-beta A4 precursor protein-binding family A member 2

Names: X11-like protein; adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); mint-2; neuron-specific X11L protein; neuronal munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130414.1 → NP_001123886.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform b

See identical proteins and their annotated locations for NP_001123886.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AB014719, AB209281, AC024474, AK310413, BC082986, BM665057, BX332225

Consensus CDS

CCDS45197.1

UniProtKB/TrEMBL

Q59G28

Related

ENSP00000409312.1, ENST00000411764.5

Conserved Domains (3) summary

cd00992
Location:645 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 523

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:556 → 639

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353788.2 → NP_001340717.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AC174469, AF047348

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Related

ENSP00000507394.1, ENST00000683413.1

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353789.2 → NP_001340718.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AC174469, AF047348

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353790.2 → NP_001340719.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AC174469, AF047348

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353791.2 → NP_001340720.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AF047348

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353792.2 → NP_001340721.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform b

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AC174469, AF047348

Consensus CDS

CCDS45197.1

UniProtKB/TrEMBL

Q59G28

Related

ENSP00000452722.1, ENST00000558330.5

Conserved Domains (3) summary

cd00992
Location:645 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 523

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:556 → 639

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353793.2 → NP_001340722.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform b

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AF047348

Consensus CDS

CCDS45197.1

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:645 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 523

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:556 → 639

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353794.2 → NP_001340723.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform b

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AF047348

Consensus CDS

CCDS45197.1

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:645 → 718

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 523

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:556 → 639

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353795.2 → NP_001340724.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform c

Status: REVIEWED

Source sequence(s)

AA861797, AC024474, AC127522, AC174469

UniProtKB/TrEMBL

Q59G28

Conserved Domains (2) summary

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353796.2 → NP_001340725.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform d

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AF047348

Conserved Domains (3) summary

cd00992
Location:361 → 434

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:67 → 239

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:272 → 355

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001353797.2 → NP_001340726.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform e

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AF047348

Conserved Domains (3) summary

cd00992
Location:349 → 422

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:67 → 227

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:260 → 343

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_001379685.1 → NP_001366614.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

Status: REVIEWED

Source sequence(s)

AC024474, AC127522, AC174469

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Related

ENSP00000453293.1, ENST00000558402.5

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
NM_005503.3 → NP_005494.2 amyloid-beta A4 precursor protein-binding family A member 2 isoform a

See identical proteins and their annotated locations for NP_005494.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AB014719, AB209281, AC024474, AK310413, BC082986, BM665057, BX332225

Consensus CDS

CCDS10022.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Related

ENSP00000454171.1, ENST00000558259.5

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

28885974..29118315

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432424.1 → XP_047288380.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_011521489.3 → XP_011519791.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

See identical proteins and their annotated locations for XP_011519791.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432416.1 → XP_047288372.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432409.1 → XP_047288365.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_047432420.1 → XP_047288376.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_011521490.3 → XP_011519792.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

See identical proteins and their annotated locations for XP_011519792.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432425.1 → XP_047288381.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_024449909.2 → XP_024305677.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2

UniProtKB/TrEMBL

Q59G28

Conserved Domains (2) summary

cd01208
Location:363 → 525

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:651 → 722

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432417.1 → XP_047288373.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432411.1 → XP_047288367.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_047432426.1 → XP_047288382.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X4
XM_047432412.1 → XP_047288368.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_047432413.1 → XP_047288369.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_047432410.1 → XP_047288366.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_047432415.1 → XP_047288371.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432419.1 → XP_047288375.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_011521488.4 → XP_011519790.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

See identical proteins and their annotated locations for XP_011519790.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432414.1 → XP_047288370.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432421.1 → XP_047288377.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432418.1 → XP_047288374.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_047432422.1 → XP_047288378.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_011521492.3 → XP_011519794.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

See identical proteins and their annotated locations for XP_011519794.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432423.1 → XP_047288379.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_017022112.3 → XP_016877601.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_011521491.2 → XP_011519793.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

See identical proteins and their annotated locations for XP_011519793.1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767

UniProtKB/TrEMBL

Q59G28

Conserved Domains (3) summary

cd00992
Location:657 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:363 → 535

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:568 → 651

PDZ; PDZ domain (Also known as DHR or GLGF)
XM_047432427.1 → XP_047288383.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X5

Reference GRCh38.p14 PATCHES

Genomic

NW_011332701.1 Reference GRCh38.p14 PATCHES

Range

1047956..1280878

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331784.1 → XP_054187759.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331766.1 → XP_054187741.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331780.1 → XP_054187755.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331773.1 → XP_054187748.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054331776.1 → XP_054187751.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054331762.1 → XP_054187737.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331781.1 → XP_054187756.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331764.1 → XP_054187739.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331785.1 → XP_054187760.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331778.1 → XP_054187753.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331787.1 → XP_054187762.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331771.1 → XP_054187746.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331783.1 → XP_054187758.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331794.1 → XP_054187769.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X4
XM_054331779.1 → XP_054187754.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331774.1 → XP_054187749.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054331782.1 → XP_054187757.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331763.1 → XP_054187738.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331761.1 → XP_054187736.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331775.1 → XP_054187750.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054331791.1 → XP_054187766.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331790.1 → XP_054187765.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331765.1 → XP_054187740.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331792.1 → XP_054187767.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331793.1 → XP_054187768.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331770.1 → XP_054187745.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331767.1 → XP_054187742.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331789.1 → XP_054187764.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331777.1 → XP_054187752.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054331772.1 → XP_054187747.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331786.1 → XP_054187761.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331769.1 → XP_054187744.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331788.1 → XP_054187763.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054331768.1 → XP_054187743.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054331795.1 → XP_054187770.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X5

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

1196581..1393362

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

26662979..26895835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054377790.1 → XP_054233765.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377769.1 → XP_054233744.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377785.1 → XP_054233760.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377776.1 → XP_054233751.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377781.1 → XP_054233756.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377765.1 → XP_054233740.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377787.1 → XP_054233762.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377767.1 → XP_054233742.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377792.1 → XP_054233767.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377779.1 → XP_054233754.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377783.1 → XP_054233758.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377794.1 → XP_054233769.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377774.1 → XP_054233749.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377789.1 → XP_054233764.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377800.1 → XP_054233775.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X4
XM_054377786.1 → XP_054233761.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377778.1 → XP_054233753.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377788.1 → XP_054233763.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377766.1 → XP_054233741.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377764.1 → XP_054233739.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377780.1 → XP_054233755.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377797.1 → XP_054233772.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377796.1 → XP_054233771.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377768.1 → XP_054233743.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377798.1 → XP_054233773.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377799.1 → XP_054233774.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377777.1 → XP_054233752.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377773.1 → XP_054233748.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377770.1 → XP_054233745.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377784.1 → XP_054233759.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377791.1 → XP_054233766.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377782.1 → XP_054233757.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X2
XM_054377775.1 → XP_054233750.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377793.1 → XP_054233768.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377772.1 → XP_054233747.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377795.1 → XP_054233770.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X3
XM_054377771.1 → XP_054233746.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X1

UniProtKB/Swiss-Prot

E9PGI4, O60571, Q5XKC0, Q99767
XM_054377801.1 → XP_054233776.1 amyloid-beta A4 precursor protein-binding family A member 2 isoform X5