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    Prl2a1 prolactin family 2, subfamily a, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 56635, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prl2a1provided by MGI
    Official Full Name
    prolactin family 2, subfamily a, member 1provided by MGI
    Primary source
    MGI:MGI:1861446
    See related
    Ensembl:ENSMUSG00000022886 AllianceGenome:MGI:1861446
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghd21; PLP-M; Prlpm
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 343.9) See more
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    Genomic context

    See Prl2a1 in Genome Data Viewer
    Location:
    13 A3.1; 13 12.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27985638..27992699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27801655..27808716)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 7, subfamily d, member 1 Neighboring gene STARR-seq mESC enhancer starr_34017 Neighboring gene STARR-seq mESC enhancer starr_34018 Neighboring gene prolactin family 7, subfamily c, member 1 Neighboring gene Prolactin family 2, subfamily c, member 1 Neighboring gene predicted gene, 22476

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prolactin-2A1
    Names
    PRL-like protein M
    growth hormone d21
    placental prolactin-like protein M
    prolactin-like protein M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019991.1NP_064375.1  prolactin-2A1 precursor

      See identical proteins and their annotated locations for NP_064375.1

      Status: PROVISIONAL

      Source sequence(s)
      AF234636
      Consensus CDS
      CCDS26407.1
      UniProtKB/Swiss-Prot
      Q9JHK0, Q9JI05
      UniProtKB/TrEMBL
      A0A0M5HDY7
      Related
      ENSMUSP00000023602.6, ENSMUST00000023602.6
      Conserved Domains (1) summary
      cd10288
      Location:30228
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      27985638..27992699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)