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    ABI1 Protein phosphatase 2C family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828714, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABI1
    Official Full Name
    Protein phosphatase 2C family protein
    Primary source
    TAIR:AT4G26080
    Locus tag
    AT4G26080
    See related
    Araport:AT4G26080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA INSENSITIVE 1; AtABI1; F20B18.190; F20B18_190; PROTEIN PHOSPHATASE 2C ABI1
    Summary
    Involved in abscisic acid (ABA) signal transduction. Negative regulator of ABA promotion of stomatal closure.
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    Genomic context

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    See ABI1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (13219915..13222376, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L18ae family Neighboring gene MAP kinase/ ERK kinase 1 Neighboring gene ncRNA Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene casein kinase 1 Neighboring gene nucleosome assembly protein1;1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UBC27-AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis. Pan W, et al. Proc Natl Acad Sci U S A, 2020 Nov 3. PMID 33077597, Free PMC Article
    2. Cold acclimation and cold-regulated gene expression in ABA mutants of Arabidopsis thaliana. Gilmour SJ, et al. Plant Mol Biol, 1991 Dec. PMID 1834244
    3. Arabidopsis ABA response gene ABI1: features of a calcium-modulated protein phosphatase. Leung J, et al. Science, 1994 Jun 3. PMID 7910981
    4. A protein phosphatase 2C involved in ABA signal transduction in Arabidopsis thaliana. Meyer K, et al. Science, 1994 Jun 3. PMID 8197457
    5. Abscisic acid-insensitive mutations provide evidence for stage-specific signal pathways regulating expression of an Arabidopsis late embryogenesis-abundant (lea) gene. Finkelstein RR. Mol Gen Genet, 1993 Apr. PMID 8492808

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
      Title: TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis.
    2. Protein Phosphatases Type 2C Group A Interact with and Regulate the Stability of ACC Synthase 7 in Arabidopsis.
      Title: Protein Phosphatases Type 2C Group A Interact with and Regulate the Stability of ACC Synthase 7 in Arabidopsis.
    3. The UBC27-AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis.
      Title: The UBC27-AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis.
    4. ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance.
      Title: ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance.
    5. ABI1, ABI2, and HAI1 promoters of PP2C are regulated by repressors; BRM ATPase contributes to the repression of PP2C gene transcription
      Title: Chromatin remodeling for the transcription of type 2C protein phosphatase genes in response to salt stress.
    6. ABI1 is involved in auxin-triggered lateral root development.ABI1 regulates HSP22 expression.
      Title: The sHSP22 Heat Shock Protein Requires the ABI1 Protein Phosphatase to Modulate Polar Auxin Transport and Downstream Responses.
    7. Data indicate that bscisic acid (ABA) signaling is repressed by group A type 2C protein phosphatases (PP2Cs), and then ABA binds to its receptor of the ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), and REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) family, which, in turn, inhibits PP2Cs and activates downstream ABA signaling.
      Title: A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors.
    8. Phosphatase ABI1 and okadaic acid-sensitive phosphatases of the PPP family are negative regulators of salt stress-activated SnRK2.4.
      Title: Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase.
    9. ABI1 acts to inhibit MAPKKK18 kinase activity, but also affects MAPKKK18 protein turnover via the ubiquitin-proteasome pathway. SnRK2.6 kinase also seems to be important for the regulation of MAPKKK18 function.
      Title: Regulation of Arabidopsis MAPKKK18 by ABI1 and SnRK2, components of the ABA signaling pathway.
    10. ABI1 regulates the activity and promotes proteasomal degradation of MKKK18.
      Title: Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118741.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein serine/threonine phosphatase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein phosphatase 2C family protein
    NP_194338.1
    • ABA INSENSITIVE 1 (ABI1); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT5G57050.1); Has 6864 Blast hits to 6731 proteins in 444 species: Archae - 4; Bacteria - 295; Metazoa - 1756; Fungi - 772; Plants - 2717; Viruses - 7; Other Eukaryotes - 1313 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13219915..13222376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118741.3 → NP_194338.1  Protein phosphatase 2C family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49597, Q0WW30, Q43717, Q94C87
      UniProtKB/TrEMBL
      A0A178V1P9, A0A5S9XWB7
      Conserved Domains (1) summary
      smart00332
      Location:119 → 420
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49597.2

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