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    ARA12 Subtilase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836871, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARA12
    Official Full Name
    Subtilase family protein
    Primary source
    TAIR:AT5G67360
    Locus tag
    AT5G67360
    See related
    Araport:AT5G67360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K8K14.8; K8K14_8
    Summary
    Encodes a subtilisin-like serine protease essential for mucilage release from seed coats.
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    Genomic context

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    See ARA12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (26871891..26874850, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene DUF1230 family protein (DUF1230)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A subtilisin-like serine protease essential for mucilage release from Arabidopsis seed coats. Rautengarten C, et al. Plant J, 2008 May. PMID 18266922
    2. Purification and characterization of serine proteases that exhibit caspase-like activity and are associated with programmed cell death in Avena sativa. Coffeen WC, et al. Plant Cell, 2004 Apr. PMID 15020745, Free PMC Article
    3. Ara12 subtilisin-like protease from Arabidopsis thaliana: purification, substrate specificity and tissue localization. Hamilton JM, et al. Biochem J, 2003 Feb 15. PMID 12413398, Free PMC Article
    4. PECTIN METHYLESTERASE INHIBITOR6 promotes Arabidopsis mucilage release by limiting methylesterification of homogalacturonan in seed coat epidermal cells. Saez-Aguayo S, et al. Plant Cell, 2013 Jan. PMID 23362209, Free PMC Article
    5. The Arabidopsis transcription factor LUH/MUM1 is required for extrusion of seed coat mucilage. Huang J, et al. Plant Physiol, 2011 Jun. PMID 21518777, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Another regulator of PME activity in seed coat epidermal cells, the subtilisin-like Ser protease SBT1.7, acts on different PMEs, as a pmei6 sbt1.7 mutant showed an additive phenotype.
      Title: PECTIN METHYLESTERASE INHIBITOR6 promotes Arabidopsis mucilage release by limiting methylesterification of homogalacturonan in seed coat epidermal cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126136.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mucilage extrusion from seed coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mucilage metabolic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    Subtilase family protein
    NP_569048.1
    • ARA12; FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: proteolysis, seed coat development, mucilage metabolic process involved seed coat development, mucilage extrusion from seed coat; LOCATED IN: extracellular region, apoplast, cell wall, plant-type cell wall; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), Proteinase inhibitor, propeptide (InterPro:IPR009020), Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398), Proteinase inhibitor I9, subtilisin propeptide (InterPro:IPR010259); BEST Arabidopsis thaliana protein match is: Subtilase family protein (TAIR:AT2G05920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26871891..26874850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126136.3 → NP_569048.1  Subtilase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_569048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65351, P80854, Q39007, Q8RWQ7
      UniProtKB/TrEMBL
      A0A5S9YHV2
      Conserved Domains (4) summary
      cd04852
      Location:103 → 576
      Peptidases_S8_3; Peptidase S8 family domain, uncharacterized subfamily 3
      COG1404
      Location:205 → 351
      AprE; Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]
      cd02120
      Location:346 → 471
      PA_subtilisin_like; PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from ...
      pfam05922
      Location:31 → 106
      Inhibitor_I9; Peptidase inhibitor I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65351.1

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