PAA1 proteasome alpha subunit A1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PAA1
Official Full Name: proteasome alpha subunit A1
Primary source: TAIR:AT5G35590
Locus tag: AT5G35590
See related: Araport:AT5G35590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 20S PROTEASOME SUBUNIT PAA1; K2K18.4; K2K18_4; proteasome alpha subunit A1
Summary: Encodes 20S proteasome subunit PAA1 (PAA1).
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Genomic context

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See PAA1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 9

Sequence:: Chromosome: 5; NC_003076.8 (13765076..13767888, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose that PAA1 and PAA2 function sequentially in copper transport over the envelope and thylakoid membrane, respectively.
Title: Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122950.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	TAS Traceable Author Statement more info	PubMed
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome alpha subunit A1

NP_198409.1

proteasome alpha subunit A1 (PAA1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: response to zinc ion, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, plasma membrane; EXPRESSED IN: cotyledon, fruit, guard cell, cultured cell; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome subunit PAA2 (TAIR:AT2G05840.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

13765076..13767888 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122950.4 → NP_198409.1 proteasome alpha subunit A1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198409.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23713, O81146, Q0WR56, Q8RWN8

UniProtKB/TrEMBL

A0A178U8E1, A0A5S9Y8P2, A0A7G2FDQ8

Conserved Domains (1) summary

cd03754
Location:8 → 220

proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...