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    UPL1 LOW protein: E3 ubiquitin ligase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842036, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPL1
    Official Full Name
    LOW protein: E3 ubiquitin ligase-like protein
    Primary source
    TAIR:AT1G55860
    Locus tag
    AT1G55860
    See related
    Araport:AT1G55860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14J16.37; ubiquitin-protein ligase 1
    Summary
    encodes a ubiquitin-protein ligase containing a HECT domain. There are six other HECT-domain UPLs in Arabidopsis.
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    Genomic context

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    See UPL1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Sequence:
    Chromosome: 1; NC_003070.9 (20879900..20893268, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Sec14p-like phosphatidylinositol transfer family protein Neighboring gene cellulose synthase like E1 Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene Pyridoxal-5'-phosphate-dependent enzyme family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UPL1 and 2, two 405 kDa ubiquitin-protein ligases from Arabidopsis thaliana related to the HECT-domain protein family. Bates PW, et al. Plant J, 1999 Oct. PMID 10571878
    2. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
    3. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001198316.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of ubiquitin ligase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW protein: E3 ubiquitin ligase-like protein
    NP_001185245.1
    • ubiquitin-protein ligase 1 (UPL1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: protein ubiquitination, ubiquitin-dependent protein catabolic process; LOCATED IN: cytosol, mitochondrion, ubiquitin ligase complex, membrane; EXPRESSED IN: guard cell, cultured cell, trichome, leaf; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), E3 ubiquitin ligase, domain of unknown function DUF913 (InterPro:IPR010314), HECT (InterPro:IPR000569), Ubiquitin interacting motif (InterPro:IPR003903), E3 ubiquitin ligase, domain of unknown function DUF908 (InterPro:IPR010309), Armadillo-type fold (InterPro:IPR016024), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: ubiquitin-protein ligase 2 (TAIR:AT1G70320.1); Has 8980 Blast hits to 7230 proteins in 418 species: Archae - 33; Bacteria - 397; Metazoa - 4053; Fungi - 1646; Plants - 643; Viruses - 68; Other Eukaryotes - 2140 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20879900..20893268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198316.2 → NP_001185245.1  LOW protein: E3 ubiquitin ligase-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I1Y3, Q8GY23, Q9LG27, Q9M7K7
      UniProtKB/TrEMBL
      A0A178WHZ8
      Conserved Domains (6) summary
      smart00119
      Location:3343 → 3678
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3319 → 3679
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14327
      Location:1273 → 1310
      UBA_atUPL1_2_like; UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins
      pfam06012
      Location:88 → 358
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:416 → 763
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2609 → 2704
      DUF4414; Domain of unknown function (DUF4414)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY23.3

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