THI6 bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THI6
Official Full Name: bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
Primary source: SGD:S000006135
Locus tag: YPL214C
See related: AllianceGenome:SGD:S000006135; FungiDB:YPL214C; VEuPathDB:YPL214C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables hydroxyethylthiazole kinase activity and thiamine-phosphate diphosphorylase activity. Involved in thiamine biosynthetic process. Located in cytosol. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See THI6 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (148569..150191, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydroxyethylthiazole kinase activity	IEA Inferred from Electronic Annotation more info
enables hydroxyethylthiazole kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine-phosphate diphosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine-phosphate diphosphorylase activity	IEA Inferred from Electronic Annotation more info
enables thiamine-phosphate diphosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in thiamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase

NP_015110.1

EC 2.5.1.3

EC 2.7.1.50

Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

148569..150191 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184028.1 → NP_015110.1 TPA: bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3F6, P41835

UniProtKB/TrEMBL

A6ZW41, B3LKL6, C7GN41, C8ZIG5, G2WNX1, N1NW91

Conserved Domains (2) summary

TIGR00694
Location:255 → 529

thiM; hydroxyethylthiazole kinase

TIGR00693
Location:11 → 225

thiE; thiamine-phosphate diphosphorylase