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    Nlrp12 NLR family, pyrin domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292541, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nlrp12provided by RGD
    Official Full Name
    NLR family, pyrin domain containing 12provided by RGD
    Primary source
    RGD:1309415
    See related
    EnsemblRapid:ENSRNOG00000060745 AllianceGenome:RGD:1309415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nalp12
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including negative regulation of protein autophosphorylation; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including dendritic cell migration; positive regulation of MHC class I biosynthetic process; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be part of canonical inflammasome complex. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 66.2), Spleen (RPKM 8.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nlrp12 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74848020..74885945)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65932610..65969873)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64506750..64543908)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 49-like Neighboring gene olfactory receptor family 6 subfamily A member L2 Neighboring gene microRNA 295-1 Neighboring gene microRNA 291b Neighboring gene microRNA 291a Neighboring gene microRNA 294 Neighboring gene microRNA 293 Neighboring gene microRNA 292 Neighboring gene microRNA 290 Neighboring gene nitric oxide synthase interacting protein, pseudogene 1 Neighboring gene solute carrier family 7 member 3 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in NALP12 cause hereditary periodic fever syndromes. Jéru I, et al. Proc Natl Acad Sci U S A, 2008 Feb 5. PMID 18230725, Free PMC Article
    2. Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. Williams KL, et al. J Immunol, 2003 Jun 1. PMID 12759408
    3. Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. Arthur JC, et al. J Immunol, 2010 Oct 15. PMID 20861349, Free PMC Article
    4. The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Truax AD, et al. Cell Host Microbe, 2018 Sep 12. PMID 30212649, Free PMC Article
    5. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Allen IC, et al. Immunity, 2012 May 25. PMID 22503542, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendritic cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Toll signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MHC class I biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of canonical inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 12
    Names
    NACHT, leucine rich repeat and PYD containing 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169142.1 → NP_001162613.1  NACHT, LRR and PYD domains-containing protein 12

      See identical proteins and their annotated locations for NP_001162613.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JW23, A6KS45
      Related
      ENSRNOP00000069711.1, ENSRNOT00000086331.3
      Conserved Domains (5) summary
      cd00116
      Location:737 → 1028
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:708 → 736
      LRR_RI; leucine-rich repeat [structural motif]
      pfam02758
      Location:12 → 90
      PYRIN; PAAD/DAPIN/Pyrin domain
      pfam05729
      Location:212 → 380
      NACHT; NACHT domain
      pfam14484
      Location:129 → 200
      FISNA; Fish-specific NACHT associated domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74848020..74885945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282937.1 → XP_063139007.1  NACHT, LRR and PYD domains-containing protein 12 isoform X1

      UniProtKB/TrEMBL
      A6KS45

    2. XM_039103730.2 → XP_038959658.1  NACHT, LRR and PYD domains-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      A6KS45
      Conserved Domains (7) summary
      sd00033
      Location:708 → 736
      LRR_RI; leucine-rich repeat [structural motif]
      pfam02758
      Location:12 → 86
      PYRIN; PAAD/DAPIN/Pyrin domain
      pfam05729
      Location:212 → 380
      NACHT; NACHT domain
      pfam14484
      Location:129 → 200
      FISNA; Fish-specific NACHT associated domain
      pfam17776
      Location:514 → 621
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:459 → 512
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:722 → 971
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. XM_039103733.1 → XP_038959661.1  NACHT, LRR and PYD domains-containing protein 12 isoform X4

      UniProtKB/TrEMBL
      A6KS45
      Conserved Domains (6) summary
      sd00033
      Location:708 → 736
      LRR_RI; leucine-rich repeat [structural motif]
      pfam02758
      Location:12 → 86
      PYRIN; PAAD/DAPIN/Pyrin domain
      pfam05729
      Location:212 → 380
      NACHT; NACHT domain
      pfam14484
      Location:129 → 200
      FISNA; Fish-specific NACHT associated domain
      pfam17779
      Location:459 → 512
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:552 → 857
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_017588882.3 → XP_017444371.1  NACHT, LRR and PYD domains-containing protein 12 isoform X3

      UniProtKB/TrEMBL
      A6KS45

    5. XM_063282938.1 → XP_063139008.1  NACHT, LRR and PYD domains-containing protein 12 isoform X3

      UniProtKB/TrEMBL
      A6KS45

    RNA

    1. XR_010064552.1 RNA Sequence

    2. XR_010064551.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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